High-resolution genotyping of HLA class I loci in children with type 1 diabetes and celiac disease
(2021) In HLA: Immune Response Genetics 97(6). p.505-511- Abstract
Objectives: HLA-DQ2 and DQ8 contribute to the strongest risk haplotypes for type 1 diabetes (T1D) and celiac disease (CD). The variation in genetic risk association is likely linked to different HLA class II loci susceptibility, but association studies of HLA class I alleles are scarce. The aim was to investigate HLA class I A, B, and C alleles polymorphisms in children with only T1D, CD, and a subgroup with both T1D and CD (T1D w/CD). Materials and methods: HLA class I A, B, and C genes were genotyped using next-generation targeted sequencing. A conditional analysis was performed on 68 children with T1D, 219 children with CD and seven children with T1D w/CD enrolled from a birth cohort study at high genetic risk children from the South... (More)
Objectives: HLA-DQ2 and DQ8 contribute to the strongest risk haplotypes for type 1 diabetes (T1D) and celiac disease (CD). The variation in genetic risk association is likely linked to different HLA class II loci susceptibility, but association studies of HLA class I alleles are scarce. The aim was to investigate HLA class I A, B, and C alleles polymorphisms in children with only T1D, CD, and a subgroup with both T1D and CD (T1D w/CD). Materials and methods: HLA class I A, B, and C genes were genotyped using next-generation targeted sequencing. A conditional analysis was performed on 68 children with T1D, 219 children with CD and seven children with T1D w/CD enrolled from a birth cohort study at high genetic risk children from the South of Sweden. Results: Among 1764 HLA class I allele variants, A*29:02:01 in T1D w/CD was associated with both T1D (OR = 21.42 [1.05, 1322.4], p = 0.0231) and CD (OR = 35 [2.36, 529.12], p = 0.0051) along with C*05:01:01 with both T1D (OR = 5.54 [1.06, 24.8], p = 0.02) and CD (OR = 6.84 [1.46, 26.01], p = 0.0077). No independent effects of HLA-B allele associations were observed in T1D w/CD. Conclusion: Although the distribution of HLA class I alleles differs between children with T1D and CD, the A*29:02:01 and C*05:01:01 alleles showed shared risk association of both diseases.
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- author
- Alshiekh, Shehab LU ; Geraghty, Daniel E. and Agardh, Daniel LU
- organization
- publishing date
- 2021-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- celiac disease, children, HLA, HLA class I, next-generation sequencing, type 1 diabetes
- in
- HLA: Immune Response Genetics
- volume
- 97
- issue
- 6
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85105062365
- pmid:33885207
- ISSN
- 2059-2302
- DOI
- 10.1111/tan.14280
- language
- English
- LU publication?
- yes
- id
- 3541d430-193e-4b39-b0aa-a8526e957080
- date added to LUP
- 2021-05-31 11:27:35
- date last changed
- 2025-04-04 14:38:33
@article{3541d430-193e-4b39-b0aa-a8526e957080,
abstract = {{<p>Objectives: HLA-DQ2 and DQ8 contribute to the strongest risk haplotypes for type 1 diabetes (T1D) and celiac disease (CD). The variation in genetic risk association is likely linked to different HLA class II loci susceptibility, but association studies of HLA class I alleles are scarce. The aim was to investigate HLA class I A, B, and C alleles polymorphisms in children with only T1D, CD, and a subgroup with both T1D and CD (T1D w/CD). Materials and methods: HLA class I A, B, and C genes were genotyped using next-generation targeted sequencing. A conditional analysis was performed on 68 children with T1D, 219 children with CD and seven children with T1D w/CD enrolled from a birth cohort study at high genetic risk children from the South of Sweden. Results: Among 1764 HLA class I allele variants, A*29:02:01 in T1D w/CD was associated with both T1D (OR = 21.42 [1.05, 1322.4], p = 0.0231) and CD (OR = 35 [2.36, 529.12], p = 0.0051) along with C*05:01:01 with both T1D (OR = 5.54 [1.06, 24.8], p = 0.02) and CD (OR = 6.84 [1.46, 26.01], p = 0.0077). No independent effects of HLA-B allele associations were observed in T1D w/CD. Conclusion: Although the distribution of HLA class I alleles differs between children with T1D and CD, the A*29:02:01 and C*05:01:01 alleles showed shared risk association of both diseases.</p>}},
author = {{Alshiekh, Shehab and Geraghty, Daniel E. and Agardh, Daniel}},
issn = {{2059-2302}},
keywords = {{celiac disease; children; HLA; HLA class I; next-generation sequencing; type 1 diabetes}},
language = {{eng}},
month = {{06}},
number = {{6}},
pages = {{505--511}},
publisher = {{Wiley-Blackwell}},
series = {{HLA: Immune Response Genetics}},
title = {{High-resolution genotyping of HLA class I loci in children with type 1 diabetes and celiac disease}},
url = {{http://dx.doi.org/10.1111/tan.14280}},
doi = {{10.1111/tan.14280}},
volume = {{97}},
year = {{2021}},
}