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Perivascular mesenchymal stem cells in the adult human brain: a future target for neuroregeneration?

Ozen, Ilknur LU ; Boix, Jordi LU and Paul-Visse, Gesine LU (2012) In Clinical and Translational Medicine 1(1).
Abstract
Perivascular adult stem cells have been isolated from several tissues, including the adult human brain. They have unique signatures resembling both pericytes and mesenchymal stem cells. Understanding the nature of these cells in their specific vascular niches is important to determine their clinical potential as a new adult stem cell source. Indeed, they have promising features in vitro in terms of multipotency, immunomodulation and secretion of growth factors and cytokines. However, their in vivo function is less known as yet. Recent emerging data show a crucial role of perivascular mesenchymal stem cells in tissue homeostasis and repair. Furthermore, these cells may play an important role in adult stem cell niche regulation and in... (More)
Perivascular adult stem cells have been isolated from several tissues, including the adult human brain. They have unique signatures resembling both pericytes and mesenchymal stem cells. Understanding the nature of these cells in their specific vascular niches is important to determine their clinical potential as a new adult stem cell source. Indeed, they have promising features in vitro in terms of multipotency, immunomodulation and secretion of growth factors and cytokines. However, their in vivo function is less known as yet. Recent emerging data show a crucial role of perivascular mesenchymal stem cells in tissue homeostasis and repair. Furthermore, these cells may play an important role in adult stem cell niche regulation and in neurodegeneration. Here we review the recent literature on perivascular mesenchymal stem cells, discuss their different in vitro functions and highlight especially the specific properties of brain-derived perivascular mesenchymal stem cells. We summarize current evidence that suggests an important in vivo function of these cells in terms of their regenerative potential that may indicate a new target cell for endogenous tissue regeneration and repair. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Clinical and Translational Medicine
volume
1
issue
1
publisher
Springer
external identifiers
  • pmid:23369339
ISSN
2001-1326
DOI
10.1186/2001-1326-1-30
language
English
LU publication?
yes
id
f1f0d72b-d865-4c01-b0d7-1fe089f453d7 (old id 3560333)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23369339?dopt=Abstract
date added to LUP
2013-03-01 11:54:25
date last changed
2016-09-20 04:12:41
@article{f1f0d72b-d865-4c01-b0d7-1fe089f453d7,
  abstract     = {Perivascular adult stem cells have been isolated from several tissues, including the adult human brain. They have unique signatures resembling both pericytes and mesenchymal stem cells. Understanding the nature of these cells in their specific vascular niches is important to determine their clinical potential as a new adult stem cell source. Indeed, they have promising features in vitro in terms of multipotency, immunomodulation and secretion of growth factors and cytokines. However, their in vivo function is less known as yet. Recent emerging data show a crucial role of perivascular mesenchymal stem cells in tissue homeostasis and repair. Furthermore, these cells may play an important role in adult stem cell niche regulation and in neurodegeneration. Here we review the recent literature on perivascular mesenchymal stem cells, discuss their different in vitro functions and highlight especially the specific properties of brain-derived perivascular mesenchymal stem cells. We summarize current evidence that suggests an important in vivo function of these cells in terms of their regenerative potential that may indicate a new target cell for endogenous tissue regeneration and repair.},
  articleno    = {30},
  author       = {Ozen, Ilknur and Boix, Jordi and Paul-Visse, Gesine},
  issn         = {2001-1326},
  language     = {eng},
  number       = {1},
  publisher    = {Springer},
  series       = {Clinical and Translational Medicine},
  title        = {Perivascular mesenchymal stem cells in the adult human brain: a future target for neuroregeneration?},
  url          = {http://dx.doi.org/10.1186/2001-1326-1-30},
  volume       = {1},
  year         = {2012},
}