Diabetes Mellitus and Elevated Copeptin Levels in Middle Age Predict Low Cognitive Speed after Long-Term Follow-Up.
(2013) In Dementia and Geriatric Cognitive Disorders 35(1-2). p.67-76- Abstract
- Background/Aims: We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. Methods: Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT). Results: Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance. Conclusion: Prevalence of diabetes mellitus and elevated... (More)
- Background/Aims: We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. Methods: Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT). Results: Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance. Conclusion: Prevalence of diabetes mellitus and elevated copeptin levels in middle age predict lower cognitive speed after long-term follow-up. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3560440
- author
- Tufvesson, Eva ; Melander, Olle LU ; Minthon, Lennart LU ; Persson, Margaretha LU ; Nilsson, Peter LU ; Struck, Joachim and Nägga, Katarina LU
- organization
-
- Cardiovascular Research - Hypertension (research group)
- Clinical Memory Research (research group)
- Internal Medicine - Epidemiology (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Dementia and Geriatric Cognitive Disorders
- volume
- 35
- issue
- 1-2
- pages
- 67 - 76
- publisher
- Karger
- external identifiers
-
- wos:000317900400006
- pmid:23364030
- scopus:84873042113
- pmid:23364030
- ISSN
- 1420-8008
- DOI
- 10.1159/000346292
- language
- English
- LU publication?
- yes
- id
- ebb9f10c-1dd5-4ff3-8e77-a19e791bbad4 (old id 3560440)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23364030?dopt=Abstract
- date added to LUP
- 2016-04-01 10:42:14
- date last changed
- 2024-01-06 23:04:03
@article{ebb9f10c-1dd5-4ff3-8e77-a19e791bbad4, abstract = {{Background/Aims: We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. Methods: Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT). Results: Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance. Conclusion: Prevalence of diabetes mellitus and elevated copeptin levels in middle age predict lower cognitive speed after long-term follow-up.}}, author = {{Tufvesson, Eva and Melander, Olle and Minthon, Lennart and Persson, Margaretha and Nilsson, Peter and Struck, Joachim and Nägga, Katarina}}, issn = {{1420-8008}}, language = {{eng}}, number = {{1-2}}, pages = {{67--76}}, publisher = {{Karger}}, series = {{Dementia and Geriatric Cognitive Disorders}}, title = {{Diabetes Mellitus and Elevated Copeptin Levels in Middle Age Predict Low Cognitive Speed after Long-Term Follow-Up.}}, url = {{https://lup.lub.lu.se/search/files/2067450/3972945.pdf}}, doi = {{10.1159/000346292}}, volume = {{35}}, year = {{2013}}, }