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Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls

Wannan, Cassandra M.J. ; Eratne, Dhamidhu ; Santillo, Alexander F. LU orcid ; Malpas, Charles ; Cilia, Brandon ; Dean, Olivia M. ; Walker, Adam ; Berk, Michael ; Bousman, Chad and Everall, Ian , et al. (2024) In Psychiatry Research 339.
Abstract

Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma... (More)

Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.

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type
Contribution to journal
publication status
published
subject
keywords
Accelerated aging, Bipolar, Depression, Neurofilament, Psychiatric disorders, Psychiatry, Schizophrenia
in
Psychiatry Research
volume
339
article number
116073
publisher
Elsevier
external identifiers
  • scopus:85198701459
  • pmid:39024892
ISSN
0165-1781
DOI
10.1016/j.psychres.2024.116073
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2024 The Authors
id
358cd91c-47f5-42d5-b1fb-a11d04cc1243
date added to LUP
2024-07-22 16:18:30
date last changed
2024-07-24 02:57:48
@article{358cd91c-47f5-42d5-b1fb-a11d04cc1243,
  abstract     = {{<p>Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.</p>}},
  author       = {{Wannan, Cassandra M.J. and Eratne, Dhamidhu and Santillo, Alexander F. and Malpas, Charles and Cilia, Brandon and Dean, Olivia M. and Walker, Adam and Berk, Michael and Bousman, Chad and Everall, Ian and Velakoulis, Dennis and Pantelis, Christos}},
  issn         = {{0165-1781}},
  keywords     = {{Accelerated aging; Bipolar; Depression; Neurofilament; Psychiatric disorders; Psychiatry; Schizophrenia}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Psychiatry Research}},
  title        = {{Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls}},
  url          = {{http://dx.doi.org/10.1016/j.psychres.2024.116073}},
  doi          = {{10.1016/j.psychres.2024.116073}},
  volume       = {{339}},
  year         = {{2024}},
}