Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls
(2024) In Psychiatry Research 339.- Abstract
Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma... (More)
Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2024-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Accelerated aging, Bipolar, Depression, Neurofilament, Psychiatric disorders, Psychiatry, Schizophrenia
- in
- Psychiatry Research
- volume
- 339
- article number
- 116073
- publisher
- Elsevier
- external identifiers
-
- scopus:85198701459
- pmid:39024892
- ISSN
- 0165-1781
- DOI
- 10.1016/j.psychres.2024.116073
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2024 The Authors
- id
- 358cd91c-47f5-42d5-b1fb-a11d04cc1243
- date added to LUP
- 2024-07-22 16:18:30
- date last changed
- 2024-07-24 02:57:48
@article{358cd91c-47f5-42d5-b1fb-a11d04cc1243, abstract = {{<p>Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.</p>}}, author = {{Wannan, Cassandra M.J. and Eratne, Dhamidhu and Santillo, Alexander F. and Malpas, Charles and Cilia, Brandon and Dean, Olivia M. and Walker, Adam and Berk, Michael and Bousman, Chad and Everall, Ian and Velakoulis, Dennis and Pantelis, Christos}}, issn = {{0165-1781}}, keywords = {{Accelerated aging; Bipolar; Depression; Neurofilament; Psychiatric disorders; Psychiatry; Schizophrenia}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Psychiatry Research}}, title = {{Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls}}, url = {{http://dx.doi.org/10.1016/j.psychres.2024.116073}}, doi = {{10.1016/j.psychres.2024.116073}}, volume = {{339}}, year = {{2024}}, }