Advanced

Gas-borne particles with tunable and highly controlled characteristics.

Messing, Maria LU ; Svensson, Christian LU ; Pagels, Joakim LU ; Meuller, Bengt LU ; Deppert, Knut LU and Rissler, Jenny LU (2013) In Nanotoxicology 7(6). p.1052-1063
Abstract
Abstract For nanotoxicology investigations of air-borne particles to provide relevant results it is ever so important that the particle exposure of, for example cells, closely resembles the "real" exposure situation, that the dosimetry is well defined, and that the characteristics of the deposited nanoparticles are known in detail. By synthesizing the particles in the gas-phase and directly depositing them on lung cells the particle deposition conditions in the lung is closely mimicked. In this work we present a setup for generation of gas-borne nanoparticles of a variety of different materials with highly controlled and tunable particle characteristics, and demonstrate the method by generation of gold particles. Particle size, number... (More)
Abstract For nanotoxicology investigations of air-borne particles to provide relevant results it is ever so important that the particle exposure of, for example cells, closely resembles the "real" exposure situation, that the dosimetry is well defined, and that the characteristics of the deposited nanoparticles are known in detail. By synthesizing the particles in the gas-phase and directly depositing them on lung cells the particle deposition conditions in the lung is closely mimicked. In this work we present a setup for generation of gas-borne nanoparticles of a variety of different materials with highly controlled and tunable particle characteristics, and demonstrate the method by generation of gold particles. Particle size, number concentration and mass of individual particles of the population are measured on-line by means of differential mobility analyzers (DMA) and an aerosol particle mass analyzer (APM) whereas primary particle size and internal structure are investigated by transmission electron microscopy. A method for 3 estimating the surface area dose from the DMA-APM measurements is applied and we further demonstrate that for the setup used, a deposition time of around 1 hour is needed for deposition onto cells in an air liquid interface chamber, using electrostatic deposition, to reach a toxicological relevant surface area dose. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nanotoxicology
volume
7
issue
6
pages
1052 - 1063
publisher
Informa Healthcare
external identifiers
  • wos:000322836800001
  • pmid:22630037
  • scopus:84881266765
ISSN
1743-5404
DOI
10.3109/17435390.2012.697589
project
MERGE
language
English
LU publication?
yes
id
35b57e2e-de39-495b-bf1e-92423e13d2f7 (old id 2608480)
date added to LUP
2012-08-22 10:55:28
date last changed
2019-03-19 01:16:36
@article{35b57e2e-de39-495b-bf1e-92423e13d2f7,
  abstract     = {Abstract For nanotoxicology investigations of air-borne particles to provide relevant results it is ever so important that the particle exposure of, for example cells, closely resembles the "real" exposure situation, that the dosimetry is well defined, and that the characteristics of the deposited nanoparticles are known in detail. By synthesizing the particles in the gas-phase and directly depositing them on lung cells the particle deposition conditions in the lung is closely mimicked. In this work we present a setup for generation of gas-borne nanoparticles of a variety of different materials with highly controlled and tunable particle characteristics, and demonstrate the method by generation of gold particles. Particle size, number concentration and mass of individual particles of the population are measured on-line by means of differential mobility analyzers (DMA) and an aerosol particle mass analyzer (APM) whereas primary particle size and internal structure are investigated by transmission electron microscopy. A method for 3 estimating the surface area dose from the DMA-APM measurements is applied and we further demonstrate that for the setup used, a deposition time of around 1 hour is needed for deposition onto cells in an air liquid interface chamber, using electrostatic deposition, to reach a toxicological relevant surface area dose.},
  author       = {Messing, Maria and Svensson, Christian and Pagels, Joakim and Meuller, Bengt and Deppert, Knut and Rissler, Jenny},
  issn         = {1743-5404},
  language     = {eng},
  number       = {6},
  pages        = {1052--1063},
  publisher    = {Informa Healthcare},
  series       = {Nanotoxicology},
  title        = {Gas-borne particles with tunable and highly controlled characteristics.},
  url          = {http://dx.doi.org/10.3109/17435390.2012.697589},
  volume       = {7},
  year         = {2013},
}