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APT-weighted MRI: Techniques, current neuro applications, and challenging issues.

Zhou, Jinyuan ; Heo, Hye-Young ; Knutsson, Linda LU ; van Zijl, Peter C M and Jiang, Shanshan (2019) In Journal of Magnetic Resonance Imaging
Abstract
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to... (More)
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Magnetic Resonance Imaging
publisher
John Wiley & Sons
external identifiers
  • pmid:30663162
  • scopus:85060350429
ISSN
1522-2586
DOI
10.1002/jmri.26645
language
English
LU publication?
yes
id
35d06584-f4d1-454b-9e76-53ca6bbc5577
date added to LUP
2019-01-22 22:39:04
date last changed
2020-01-22 07:25:11
@article{35d06584-f4d1-454b-9e76-53ca6bbc5577,
  abstract     = {Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo.},
  author       = {Zhou, Jinyuan and Heo, Hye-Young  and Knutsson, Linda and van Zijl, Peter C M and Jiang, Shanshan},
  issn         = {1522-2586},
  language     = {eng},
  month        = {01},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {APT-weighted MRI: Techniques, current neuro applications, and challenging issues.},
  url          = {http://dx.doi.org/10.1002/jmri.26645},
  doi          = {10.1002/jmri.26645},
  year         = {2019},
}