APT-weighted MRI: Techniques, current neuro applications, and challenging issues.
Zhou, Jinyuan ; Heo, Hye-Young ; Knutsson, Linda LU
; van Zijl, Peter C M
and Jiang, Shanshan
(2019)
In Journal of Magnetic Resonance Imaging
- Abstract
- Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to... (More)
- Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/35d06584-f4d1-454b-9e76-53ca6bbc5577
- author
- Zhou, Jinyuan
; Heo, Hye-Young
; Knutsson, Linda
LU
; van Zijl, Peter C M
and Jiang, Shanshan
- organization
- publishing date
- 2019-01-20
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Magnetic Resonance Imaging
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:30663162
- scopus:85060350429
- ISSN
- 1522-2586
- DOI
- 10.1002/jmri.26645
- language
- English
- LU publication?
- yes
- id
- 35d06584-f4d1-454b-9e76-53ca6bbc5577
- date added to LUP
- 2019-01-22 22:39:04
- date last changed
- 2022-04-25 20:22:55
@article{35d06584-f4d1-454b-9e76-53ca6bbc5577,
abstract = {{Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo.}},
author = {{Zhou, Jinyuan and Heo, Hye-Young and Knutsson, Linda and van Zijl, Peter C M and Jiang, Shanshan}},
issn = {{1522-2586}},
language = {{eng}},
month = {{01}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Magnetic Resonance Imaging}},
title = {{APT-weighted MRI: Techniques, current neuro applications, and challenging issues.}},
url = {{http://dx.doi.org/10.1002/jmri.26645}},
doi = {{10.1002/jmri.26645}},
year = {{2019}},
}