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A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia

Soltesz, Kristian LU ; van Heusden, Klaske; Hast, Martin LU ; Ansermino, J. Mark and Dumont, Guy A. (2016) American Control Conference, 2016 p.4877-4882
Abstract
This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Proceedings of the 2016 American Control Conference
pages
4877 - 4882
publisher
Institute of Electrical and Electronics Engineers Inc.
conference name
American Control Conference, 2016
conference location
Boston, United States
conference dates
2016-07-06 - 2016-07-08
external identifiers
  • scopus:84992159390
ISBN
978-1-4673-8682-1
DOI
10.1109/ACC.2016.7526125
language
English
LU publication?
yes
id
35d2acdc-c0e0-4d61-8a1d-8c26bfc97065 (old id 8570875)
date added to LUP
2016-01-28 16:53:53
date last changed
2019-06-25 02:46:53
@inproceedings{35d2acdc-c0e0-4d61-8a1d-8c26bfc97065,
  abstract     = {This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.},
  author       = {Soltesz, Kristian and van Heusden, Klaske and Hast, Martin and Ansermino, J. Mark and Dumont, Guy A.},
  isbn         = {978-1-4673-8682-1},
  language     = {eng},
  location     = {Boston, United States},
  pages        = {4877--4882},
  publisher    = {Institute of Electrical and Electronics Engineers Inc.},
  title        = {A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia},
  url          = {http://dx.doi.org/10.1109/ACC.2016.7526125},
  year         = {2016},
}