Modulation of the Coagulation System During Severe Streptococcal Disease.
Shannon, Oonagh LU ; Herwald, Heiko LU
and Oehmcke, Sonja
LU
(2012)
In Current Topics in Microbiology and Immunology
- Abstract
- Haemostasis is maintained by a tightly regulated coagulation system that comprises platelets, procoagulant proteins, and anticoagulant proteins. During the local and systemic response to bacterial infection, the coagulation system becomes activated, and contributes to the pathophysiological response to infection. The significant human pathogen, Streptococcus pyogenes has multiple strategies to modulate coagulation. This can range from systemic activation of the intrinsic and extrinsic pathway of coagulation to local stimulation of fibrinolysis. Such diverse effects on this host system imply a finely tuned host-bacteria interaction. The molecular mechanisms that underlie this modulation of the coagulation system are discussed in this review.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3347423
- author
- Shannon, Oonagh
LU
; Herwald, Heiko
LU
and Oehmcke, Sonja
LU
- organization
- publishing date
- 2012-12-08
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Topics in Microbiology and Immunology
- publisher
- Springer
- external identifiers
-
- pmid:23224709
- wos:000330612100009
- scopus:84880434656
- ISSN
- 0070-217X
- DOI
- 10.1007/82_2012_283
- language
- English
- LU publication?
- yes
- id
- 36095c7b-d304-48c9-8668-00abe97f14b6 (old id 3347423)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23224709?dopt=Abstract
- date added to LUP
- 2016-04-04 09:09:38
- date last changed
- 2022-02-28 06:37:41
@article{36095c7b-d304-48c9-8668-00abe97f14b6,
abstract = {{Haemostasis is maintained by a tightly regulated coagulation system that comprises platelets, procoagulant proteins, and anticoagulant proteins. During the local and systemic response to bacterial infection, the coagulation system becomes activated, and contributes to the pathophysiological response to infection. The significant human pathogen, Streptococcus pyogenes has multiple strategies to modulate coagulation. This can range from systemic activation of the intrinsic and extrinsic pathway of coagulation to local stimulation of fibrinolysis. Such diverse effects on this host system imply a finely tuned host-bacteria interaction. The molecular mechanisms that underlie this modulation of the coagulation system are discussed in this review.}},
author = {{Shannon, Oonagh and Herwald, Heiko and Oehmcke, Sonja}},
issn = {{0070-217X}},
language = {{eng}},
month = {{12}},
publisher = {{Springer}},
series = {{Current Topics in Microbiology and Immunology}},
title = {{Modulation of the Coagulation System During Severe Streptococcal Disease.}},
url = {{http://dx.doi.org/10.1007/82_2012_283}},
doi = {{10.1007/82_2012_283}},
year = {{2012}},
}