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Comparative study of the microvascular blood flow in the intestinal wall, wound contraction and fluid evacuation during negative pressure wound therapy in laparostomy using the V.A.C. abdominal dressing and the ABThera open abdomen negative pressure therapy system.

Lindstedt Ingemansson, Sandra LU ; Malmsjö, Malin LU ; Hlebowicz, Joanna LU and Ingemansson, Richard LU (2015) In International Wound Journal 12(1). p.83-88
Abstract
To compare the changes in microvascular blood flow in the small intestinal wall, wound contraction and fluid evacuation, using the established V.A.C. abdominal dressing (VAC dressing) and a new abdominal dressing, the ABThera open abdomen negative pressure therapy system (ABThera dressing), in negative pressure wound therapy (NPWT). Midline incisions were made in 12 pigs, which were subjected to treatment with NPWT using the VAC or ABThera dressing. The microvascular blood flow in the intestinal wall, were measured before and after the application at topical negative pressures of -50, -75 and -125 mmHg, using laser Doppler velocimetry. Wound contraction and fluid evacuation were also measured. Baseline blood flow was defined as 100% in all... (More)
To compare the changes in microvascular blood flow in the small intestinal wall, wound contraction and fluid evacuation, using the established V.A.C. abdominal dressing (VAC dressing) and a new abdominal dressing, the ABThera open abdomen negative pressure therapy system (ABThera dressing), in negative pressure wound therapy (NPWT). Midline incisions were made in 12 pigs, which were subjected to treatment with NPWT using the VAC or ABThera dressing. The microvascular blood flow in the intestinal wall, were measured before and after the application at topical negative pressures of -50, -75 and -125 mmHg, using laser Doppler velocimetry. Wound contraction and fluid evacuation were also measured. Baseline blood flow was defined as 100% in all settings. The blood flow was significantly reduced, to 64·6 ± 6·7% (P < 0·05) after the application of -50 mmHg using the VAC dressing, and to 65·3 ± 9·6% (P < 0·05) after the application of -50 mmHg with the ABThera dressing. The blood flow was significantly reduced, to 39·6 ± 6·7% (P < 0·05) after the application of -125 mmHg using VAC, and to 40·5 ± 6·2% (P < 0·05) after the application of -125 mmHg with ABThera. No significant difference in the reduction in blood flow could be observed between the two groups. The ABThera system gave significantly better fluid evacuation from the wound compared to the VAC system. There was no difference between the dressings regarding the reduction in blood flow, but the ABThera dressing afforded better drainage of the abdomen and better wound contraction than the VAC dressing. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Wound Journal
volume
12
issue
1
pages
83 - 88
publisher
Wiley-Blackwell
external identifiers
  • pmid:23517436
  • wos:000348851700014
  • scopus:84921438281
ISSN
1742-481X
DOI
10.1111/iwj.12056
language
English
LU publication?
yes
id
dfb5c926-9e43-4c3f-bde9-c96bab858538 (old id 3627832)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23517436?dopt=Abstract
date added to LUP
2013-04-07 15:46:49
date last changed
2017-11-19 03:08:47
@article{dfb5c926-9e43-4c3f-bde9-c96bab858538,
  abstract     = {To compare the changes in microvascular blood flow in the small intestinal wall, wound contraction and fluid evacuation, using the established V.A.C. abdominal dressing (VAC dressing) and a new abdominal dressing, the ABThera open abdomen negative pressure therapy system (ABThera dressing), in negative pressure wound therapy (NPWT). Midline incisions were made in 12 pigs, which were subjected to treatment with NPWT using the VAC or ABThera dressing. The microvascular blood flow in the intestinal wall, were measured before and after the application at topical negative pressures of -50, -75 and -125 mmHg, using laser Doppler velocimetry. Wound contraction and fluid evacuation were also measured. Baseline blood flow was defined as 100% in all settings. The blood flow was significantly reduced, to 64·6 ± 6·7% (P &lt; 0·05) after the application of -50 mmHg using the VAC dressing, and to 65·3 ± 9·6% (P &lt; 0·05) after the application of -50 mmHg with the ABThera dressing. The blood flow was significantly reduced, to 39·6 ± 6·7% (P &lt; 0·05) after the application of -125 mmHg using VAC, and to 40·5 ± 6·2% (P &lt; 0·05) after the application of -125 mmHg with ABThera. No significant difference in the reduction in blood flow could be observed between the two groups. The ABThera system gave significantly better fluid evacuation from the wound compared to the VAC system. There was no difference between the dressings regarding the reduction in blood flow, but the ABThera dressing afforded better drainage of the abdomen and better wound contraction than the VAC dressing.},
  author       = {Lindstedt Ingemansson, Sandra and Malmsjö, Malin and Hlebowicz, Joanna and Ingemansson, Richard},
  issn         = {1742-481X},
  language     = {eng},
  number       = {1},
  pages        = {83--88},
  publisher    = {Wiley-Blackwell},
  series       = {International Wound Journal},
  title        = {Comparative study of the microvascular blood flow in the intestinal wall, wound contraction and fluid evacuation during negative pressure wound therapy in laparostomy using the V.A.C. abdominal dressing and the ABThera open abdomen negative pressure therapy system.},
  url          = {http://dx.doi.org/10.1111/iwj.12056},
  volume       = {12},
  year         = {2015},
}