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Effects of Bilberry (Vaccinium myrtillus) in Combination with Lactic Acid Bacteria on Intestinal Oxidative Stress Induced by Ischemia-Reperfusion in Mouse.

Jakesevic, Maja ; Xu, Jie ; Aaby, Kjersti ; Jeppsson, Bengt LU ; Ahrné, Siv and Molin, Göran (2013) In Journal of Agricultural and Food Chemistry 61(14). p.3468-3478
Abstract
Intestinal ischemia-reperfusion (I/R) results in oxidative stress, inflammation, and tissue injuries. The present study investigates the antioxidative and anti-inflammatory effects of a dietary supplement of bilberry, either alone or in combination with Lactobacillus plantarum RESO56, L. plantarum HEAL19, or Pediococcus acidilactici JAM046, in an I/R-induced model for oxidative stress in mice. A bilberry diet without addition of bacteria significantly decreased both lipid peroxidation (p = 0.001) and mucosal injury in the ileum. Of 14 anthocyanins identified in bilberry, anthocyanin arabinosides were the most resistant to absorption and microbial degradation in the intestines. Cyanidin-3-glucoside and delphinidin-3-glucoside seemed to be... (More)
Intestinal ischemia-reperfusion (I/R) results in oxidative stress, inflammation, and tissue injuries. The present study investigates the antioxidative and anti-inflammatory effects of a dietary supplement of bilberry, either alone or in combination with Lactobacillus plantarum RESO56, L. plantarum HEAL19, or Pediococcus acidilactici JAM046, in an I/R-induced model for oxidative stress in mice. A bilberry diet without addition of bacteria significantly decreased both lipid peroxidation (p = 0.001) and mucosal injury in the ileum. Of 14 anthocyanins identified in bilberry, anthocyanin arabinosides were the most resistant to absorption and microbial degradation in the intestines. Cyanidin-3-glucoside and delphinidin-3-glucoside seemed to be mostly absorbed in the stomach and upper part of the small intestine, while malvidin-3-galactoside, peonidin-3-glucoside, peonidin-3-galactoside, and petunidin-3-galactoside seemed to be digested by the microbiota in the cecum. Bilberry strongly influenced the composition of the cecal microbiota. In conclusion, a food supplement of bilberry protected small intestine against oxidative stress and inflammation induced by ischemia-reperfusion. (Less)
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; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Agricultural and Food Chemistry
volume
61
issue
14
pages
3468 - 3478
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000317548500015
  • pmid:23488931
  • scopus:84876121798
ISSN
0021-8561
DOI
10.1021/jf400203h
language
English
LU publication?
yes
id
bf1672aa-8bb0-44d1-9dd9-bc64988516ab (old id 3628200)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23488931?dopt=Abstract
date added to LUP
2016-04-01 10:04:37
date last changed
2020-09-30 01:13:51
@article{bf1672aa-8bb0-44d1-9dd9-bc64988516ab,
  abstract     = {Intestinal ischemia-reperfusion (I/R) results in oxidative stress, inflammation, and tissue injuries. The present study investigates the antioxidative and anti-inflammatory effects of a dietary supplement of bilberry, either alone or in combination with Lactobacillus plantarum RESO56, L. plantarum HEAL19, or Pediococcus acidilactici JAM046, in an I/R-induced model for oxidative stress in mice. A bilberry diet without addition of bacteria significantly decreased both lipid peroxidation (p = 0.001) and mucosal injury in the ileum. Of 14 anthocyanins identified in bilberry, anthocyanin arabinosides were the most resistant to absorption and microbial degradation in the intestines. Cyanidin-3-glucoside and delphinidin-3-glucoside seemed to be mostly absorbed in the stomach and upper part of the small intestine, while malvidin-3-galactoside, peonidin-3-glucoside, peonidin-3-galactoside, and petunidin-3-galactoside seemed to be digested by the microbiota in the cecum. Bilberry strongly influenced the composition of the cecal microbiota. In conclusion, a food supplement of bilberry protected small intestine against oxidative stress and inflammation induced by ischemia-reperfusion.},
  author       = {Jakesevic, Maja and Xu, Jie and Aaby, Kjersti and Jeppsson, Bengt and Ahrné, Siv and Molin, Göran},
  issn         = {0021-8561},
  language     = {eng},
  number       = {14},
  pages        = {3468--3478},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Journal of Agricultural and Food Chemistry},
  title        = {Effects of Bilberry (Vaccinium myrtillus) in Combination with Lactic Acid Bacteria on Intestinal Oxidative Stress Induced by Ischemia-Reperfusion in Mouse.},
  url          = {http://dx.doi.org/10.1021/jf400203h},
  doi          = {10.1021/jf400203h},
  volume       = {61},
  year         = {2013},
}