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Design and clinical evaluation of robust PID control of propofol anesthesia in children

van Heusden, Klaske; Dumont, Guy A.; Soltesz, Kristian LU ; Petersen, Christian L.; Umedaly, Aryannah; West, Nicholas and Ansermino, J. Mark (2014) In IEEE Transactions on Control Systems Technology 22(2). p.491-501
Abstract
This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure... (More)
This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anesthesia, robust control, clinical trials, PID control
in
IEEE Transactions on Control Systems Technology
volume
22
issue
2
pages
491 - 501
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • wos:000331965600007
  • scopus:84897597903
ISSN
1558-0865
DOI
10.1109/TCST.2013.2260543
project
LCCC
language
English
LU publication?
yes
id
2151c984-6a64-44f2-aaca-141099a31fcf (old id 3634156)
date added to LUP
2013-04-24 10:59:12
date last changed
2017-10-29 03:59:34
@article{2151c984-6a64-44f2-aaca-141099a31fcf,
  abstract     = {This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects.},
  author       = {van Heusden, Klaske and Dumont, Guy A. and Soltesz, Kristian and Petersen, Christian L. and Umedaly, Aryannah and West, Nicholas and Ansermino, J. Mark},
  issn         = {1558-0865},
  keyword      = {anesthesia,robust control,clinical trials,PID control},
  language     = {eng},
  number       = {2},
  pages        = {491--501},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Control Systems Technology},
  title        = {Design and clinical evaluation of robust PID control of propofol anesthesia in children},
  url          = {http://dx.doi.org/10.1109/TCST.2013.2260543},
  volume       = {22},
  year         = {2014},
}