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Nucleolar proteins with altered expression in leukemic cell lines.

Teittinen, Kaisa J; Kärkkäinen, Pauliina; Salonen, Johanna; Rönnholm, Gunilla; Korkeamäki, Hanna; Vihinen, Mauno LU ; Kalkkinen, Nisse and Lohi, Olli (2012) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 36(2). p.232-236
Abstract
The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and TAR-DNA-binding protein-43 (TDP-43) were strongly expressed in the nucleoli of the pre-B-ALL cell line MHH-CALL3. Our results demonstrate that leukemic cells have differences in their nucleolar protein composition, and suggest that it may be possible to exploit these differences in identification of leukemia subtypes.
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Repressor Proteins: metabolism, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: metabolism, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: diagnosis, Nuclear Proteins: metabolism, Cell Nucleolus: metabolism, DNA-Binding Proteins: metabolism, Tumor Markers, Biological: metabolism
in
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
volume
36
issue
2
pages
232 - 236
publisher
Elsevier
external identifiers
  • pmid:21783252
  • scopus:84855194324
ISSN
1873-5835
DOI
10.1016/j.leukres.2011.06.038
language
English
LU publication?
no
id
b8afcc29-3609-41b6-877f-09d899d16f09 (old id 3634639)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21783252?dopt=Abstract
date added to LUP
2013-06-12 20:45:02
date last changed
2017-01-01 07:38:20
@article{b8afcc29-3609-41b6-877f-09d899d16f09,
  abstract     = {The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and TAR-DNA-binding protein-43 (TDP-43) were strongly expressed in the nucleoli of the pre-B-ALL cell line MHH-CALL3. Our results demonstrate that leukemic cells have differences in their nucleolar protein composition, and suggest that it may be possible to exploit these differences in identification of leukemia subtypes.},
  author       = {Teittinen, Kaisa J and Kärkkäinen, Pauliina and Salonen, Johanna and Rönnholm, Gunilla and Korkeamäki, Hanna and Vihinen, Mauno and Kalkkinen, Nisse and Lohi, Olli},
  issn         = {1873-5835},
  keyword      = {Repressor Proteins: metabolism,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: metabolism,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: diagnosis,Nuclear Proteins: metabolism,Cell Nucleolus: metabolism,DNA-Binding Proteins: metabolism,Tumor Markers,Biological: metabolism},
  language     = {eng},
  number       = {2},
  pages        = {232--236},
  publisher    = {Elsevier},
  series       = {Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis},
  title        = {Nucleolar proteins with altered expression in leukemic cell lines.},
  url          = {http://dx.doi.org/10.1016/j.leukres.2011.06.038},
  volume       = {36},
  year         = {2012},
}