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CD103 + CD11b + mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

Flores-Langarica, A.; Müller Luda, K. LU ; Persson, E. K. LU ; Cook, C. N.; Bobat, S.; Marshall, J. L.; Dahlgren, M. W. LU ; Hägerbrand, K. LU ; Toellner, K. M. and Goodall, M. D., et al. (2018) In Mucosal Immunology 11(3). p.681-692
Abstract

Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103 + CD11b + (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103 + CD11b ' (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells... (More)

Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103 + CD11b + (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103 + CD11b ' (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α 4 β 7 +, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.

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published
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Mucosal Immunology
volume
11
issue
3
pages
12 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85047973979
ISSN
1933-0219
DOI
10.1038/mi.2017.105
language
English
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yes
id
367ad17f-a836-4b6b-81f6-b7a9e1b64609
date added to LUP
2018-06-14 13:49:59
date last changed
2018-06-15 03:00:02
@article{367ad17f-a836-4b6b-81f6-b7a9e1b64609,
  abstract     = {<p>Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103 + CD11b + (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103 + CD11b ' (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α 4 β 7 +, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.</p>},
  author       = {Flores-Langarica, A. and Müller Luda, K. and Persson, E. K. and Cook, C. N. and Bobat, S. and Marshall, J. L. and Dahlgren, M. W. and Hägerbrand, K. and Toellner, K. M. and Goodall, M. D. and Withers, D. R. and Henderson, I. R. and Johansson Lindbom, B. and Cunningham, A. F. and Agace, W. W.},
  issn         = {1933-0219},
  language     = {eng},
  month        = {05},
  number       = {3},
  pages        = {681--692},
  publisher    = {Nature Publishing Group},
  series       = {Mucosal Immunology},
  title        = {CD103 + CD11b + mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin},
  url          = {http://dx.doi.org/10.1038/mi.2017.105},
  volume       = {11},
  year         = {2018},
}