Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.
(2003) In International journal of experimental diabesity research 4(1). p.35-44- Abstract
- Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have... (More)
- Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P (Less)
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- author
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International journal of experimental diabesity research
- volume
- 4
- issue
- 1
- pages
- 35 - 44
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:0042008054
- DOI
- 10.1080/15438600303733
- language
- English
- LU publication?
- yes
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- 36c49321-1314-492d-9366-f3647b411806 (old id 1127426)
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- 2016-04-04 10:38:09
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- 2022-04-08 05:53:59
@article{36c49321-1314-492d-9366-f3647b411806, abstract = {{Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P}}, author = {{Niklasson, Bo and Heller, Knud E and Schønecker, Bryan and Bildsøe, Mogens and Daniels, Terri and Hampe, Christiane S and Widlund, Per and Simonson, William T and Schaefer, Jonathan B and Rutledge, Elizabeth and Bekris, Lynn and Lindberg, A Michael and Johansson, Susanne and Ortqvist, Eva and Persson, Bengt and Lernmark, Åke}}, language = {{eng}}, number = {{1}}, pages = {{35--44}}, publisher = {{Taylor & Francis}}, series = {{International journal of experimental diabesity research}}, title = {{Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.}}, url = {{http://dx.doi.org/10.1080/15438600303733}}, doi = {{10.1080/15438600303733}}, volume = {{4}}, year = {{2003}}, }