Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening
(2006) In Langmuir 22(3). p.906-910- Abstract
- Amorphous drug nanosuspensions are prone to particle growth due to Ostwald ripening. By incorporating a second component of extremely low aqueous solubility, Ostwald ripening can be inhibited. These studies indicate that to inhibit ripening, the drug/inhibitor mixture (in the particles) must form a single phase. The drug/inhibitor mixture can be characterized by the interaction parameter chi using the Bragg-Williams theory, in which single phase mixtures are obtained for chi < 2. The chi parameter can be calculated from the (crystalline) solubility of the drug in the inhibitor, provided the inhibitor is a liquid, and the melting entropy and temperature of the drug.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/418105
- author
- Lindfors, L ; Skantze, P ; Skantze, U ; Rasmusson, M ; Zackrisson, A and Olsson, Ulf LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langmuir
- volume
- 22
- issue
- 3
- pages
- 906 - 910
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000235068100014
- scopus:33244462200
- pmid:16430247
- ISSN
- 0743-7463
- DOI
- 10.1021/la0523661
- language
- English
- LU publication?
- yes
- id
- 36d5b0ea-fa1f-4d97-a08e-8ae6aa000e85 (old id 418105)
- date added to LUP
- 2016-04-01 12:37:00
- date last changed
- 2022-04-13 21:22:49
@article{36d5b0ea-fa1f-4d97-a08e-8ae6aa000e85, abstract = {{Amorphous drug nanosuspensions are prone to particle growth due to Ostwald ripening. By incorporating a second component of extremely low aqueous solubility, Ostwald ripening can be inhibited. These studies indicate that to inhibit ripening, the drug/inhibitor mixture (in the particles) must form a single phase. The drug/inhibitor mixture can be characterized by the interaction parameter chi using the Bragg-Williams theory, in which single phase mixtures are obtained for chi < 2. The chi parameter can be calculated from the (crystalline) solubility of the drug in the inhibitor, provided the inhibitor is a liquid, and the melting entropy and temperature of the drug.}}, author = {{Lindfors, L and Skantze, P and Skantze, U and Rasmusson, M and Zackrisson, A and Olsson, Ulf}}, issn = {{0743-7463}}, language = {{eng}}, number = {{3}}, pages = {{906--910}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Langmuir}}, title = {{Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening}}, url = {{http://dx.doi.org/10.1021/la0523661}}, doi = {{10.1021/la0523661}}, volume = {{22}}, year = {{2006}}, }