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Ruling out risks in medical research

Anttila, Sten LU ; Persson, Johannes LU ; Rosén, Måns ; Vareman, Niklas LU ; Vitols, Sigurd and Sahlin, Nils-Eric LU (2019) In Journal of Risk Research 22(6). p.796-802
Abstract
In medical research, it is not unusual that risks are ruled out without any specification the exact risk that was ruled out. This makes it difficult to balance expected health benefits and risk of harm when choosing between alternative treatment options. International guidelines for reporting medical research results are sufficiently specific when it comes to establishing health benefits. However, there is a lack of standards for reporting on ruling out risks. We argue that transparency is needed, as in the case of non-inferiority trials. The Consolidated Standards of Reporting Trials and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements should be revised accordingly.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ruling out risks, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), value judgment, transparency, risk margin, Consolidated Standards of Reporting Trials (CONSORT)
in
Journal of Risk Research
volume
22
issue
6
pages
796 - 802
publisher
Routledge
external identifiers
  • scopus:85063081055
ISSN
1366-9877
DOI
10.1080/13669877.2019.1586750
project
Science and Proven Experience
language
English
LU publication?
yes
id
36f63c3a-fa7c-4bca-9cdb-3f645a963885
date added to LUP
2018-04-12 11:37:19
date last changed
2020-01-13 00:37:43
@article{36f63c3a-fa7c-4bca-9cdb-3f645a963885,
  abstract     = {In medical research, it is not unusual that risks are ruled out without any specification the exact risk that was ruled out. This makes it difficult to balance expected health benefits and risk of harm when choosing between alternative treatment options. International guidelines for reporting medical research results are sufficiently specific when it comes to establishing health benefits. However, there is a lack of standards for reporting on ruling out risks. We argue that transparency is needed, as in the case of non-inferiority trials. The Consolidated Standards of Reporting Trials and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements should be revised accordingly.},
  author       = {Anttila, Sten and Persson, Johannes and Rosén, Måns and Vareman, Niklas and Vitols, Sigurd and Sahlin, Nils-Eric},
  issn         = {1366-9877},
  language     = {eng},
  month        = {03},
  number       = {6},
  pages        = {796--802},
  publisher    = {Routledge},
  series       = {Journal of Risk Research},
  title        = {Ruling out risks in medical research},
  url          = {https://lup.lub.lu.se/search/ws/files/61992902/Ruling_out_risks_in_medical_research.pdf},
  doi          = {10.1080/13669877.2019.1586750},
  volume       = {22},
  year         = {2019},
}