Comparison of four neuropathological scales for Alzheimer's disease.
Brunnström, Hans LU
and Englund, Elisabet
LU
(2011)
In Clinical Neuropathology
30(2).
p.56-69
- Abstract
- Objective: There are several neuropathological scales for staging of Alzheimer pathology. The system proposed by Braak and Braak is based on the topographic distribution of neurofibrillary tangles and neuropil threads, while that of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is based on the quantity of neocortical neuritic plaques. A combination of the Braak and CERAD staging scales was recommended by the National Institute on Aging and Reagan Institute (NIA-RI). The Poly-Pathology Alzheimer's Disease assessment, nine areas (PPAD9) is a staging system based on the extent of neuronal degeneration, microvacuolization, cytoarchitectural disorder and gliosis, in addition to neurofibrillary tangles and neuritic... (More)
- Objective: There are several neuropathological scales for staging of Alzheimer pathology. The system proposed by Braak and Braak is based on the topographic distribution of neurofibrillary tangles and neuropil threads, while that of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is based on the quantity of neocortical neuritic plaques. A combination of the Braak and CERAD staging scales was recommended by the National Institute on Aging and Reagan Institute (NIA-RI). The Poly-Pathology Alzheimer's Disease assessment, nine areas (PPAD9) is a staging system based on the extent of neuronal degeneration, microvacuolization, cytoarchitectural disorder and gliosis, in addition to neurofibrillary tangles and neuritic plaques, in nine cerebral regions. The aim of the present study was to critically compare these four neuropathological staging scales. Methods: We assessed the Alzheimer pathology, using the four scales, in 43 patients with various dementia disorders, with focus on concordance and differences between the staging systems. Results: Comparing the staging systems, the Spearman's rho value for PPAD9 vs. Braak was 0.65, for PPAD9 vs. CERAD 0.72, for PPAD9 vs. NIA-RI 0.67, and for Braak vs. CERAD 0.46. Conclusion: The correlation between the neuropathological staging systems was suboptimal, and we conclude that the choice of staging system affects the evaluation of Alzheimer pathology, and hence the final diagnosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1831715
- author
- Brunnström, Hans
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Neuropathology
- volume
- 30
- issue
- 2
- pages
- 56 - 69
- publisher
- Dustri-Verlag
- external identifiers
-
- pmid:21329614
- wos:000288625100003
- scopus:79952414387
- ISSN
- 0722-5091
- DOI
- 10.5414/NPP30056
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 3700f7c2-337a-44c5-a72c-8ae53c84e28d (old id 1831715)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21329614?dopt=Abstract
- date added to LUP
- 2016-04-04 09:45:46
- date last changed
- 2022-01-29 19:26:36
@article{3700f7c2-337a-44c5-a72c-8ae53c84e28d,
abstract = {{Objective: There are several neuropathological scales for staging of Alzheimer pathology. The system proposed by Braak and Braak is based on the topographic distribution of neurofibrillary tangles and neuropil threads, while that of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is based on the quantity of neocortical neuritic plaques. A combination of the Braak and CERAD staging scales was recommended by the National Institute on Aging and Reagan Institute (NIA-RI). The Poly-Pathology Alzheimer's Disease assessment, nine areas (PPAD9) is a staging system based on the extent of neuronal degeneration, microvacuolization, cytoarchitectural disorder and gliosis, in addition to neurofibrillary tangles and neuritic plaques, in nine cerebral regions. The aim of the present study was to critically compare these four neuropathological staging scales. Methods: We assessed the Alzheimer pathology, using the four scales, in 43 patients with various dementia disorders, with focus on concordance and differences between the staging systems. Results: Comparing the staging systems, the Spearman's rho value for PPAD9 vs. Braak was 0.65, for PPAD9 vs. CERAD 0.72, for PPAD9 vs. NIA-RI 0.67, and for Braak vs. CERAD 0.46. Conclusion: The correlation between the neuropathological staging systems was suboptimal, and we conclude that the choice of staging system affects the evaluation of Alzheimer pathology, and hence the final diagnosis.}},
author = {{Brunnström, Hans and Englund, Elisabet}},
issn = {{0722-5091}},
language = {{eng}},
number = {{2}},
pages = {{56--69}},
publisher = {{Dustri-Verlag}},
series = {{Clinical Neuropathology}},
title = {{Comparison of four neuropathological scales for Alzheimer's disease.}},
url = {{http://dx.doi.org/10.5414/NPP30056}},
doi = {{10.5414/NPP30056}},
volume = {{30}},
year = {{2011}},
}