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Incidental findings and their handling in the Swedish CArdioPulmonary bioimage study (SCAPIS)

Johnsson, Åse ; Angerås, Oskar ; Blomberg, Anders ; Erlinge, David LU orcid ; Flinck, Agneta ; Janson, Christer ; Markstad, Hanna LU ; Persson, Jonas ; Persson, H. Lennart and Swahn, Eva , et al. (2017) In Medical Radiology p.91-101
Abstract

The Swedish CArdioPulmonary bioImage Study (SCAPIS) combines the use of new imaging technologies, large-scale proteomics/metabolomics/genomics, and epidemiological analyses to extensively characterize a Swedish cohort of 30,000 men and women aged between 50 and 64 years. Its main aims are to improve risk prediction and to optimize our ability to study mechanisms of cardiopulmonary diseases. SCAPIS is currently recruiting at six sites in Sweden, and a pilot study was conducted in 2012 to test the feasibility of the comprehensive study protocol. In the planning phase, it was recognized that the detailed phenotyping used in SCAPIS would identify a large number of clinical findings in need of medical attention. This was confirmed by... (More)

The Swedish CArdioPulmonary bioImage Study (SCAPIS) combines the use of new imaging technologies, large-scale proteomics/metabolomics/genomics, and epidemiological analyses to extensively characterize a Swedish cohort of 30,000 men and women aged between 50 and 64 years. Its main aims are to improve risk prediction and to optimize our ability to study mechanisms of cardiopulmonary diseases. SCAPIS is currently recruiting at six sites in Sweden, and a pilot study was conducted in 2012 to test the feasibility of the comprehensive study protocol. In the planning phase, it was recognized that the detailed phenotyping used in SCAPIS would identify a large number of clinical findings in need of medical attention. This was confirmed by evaluation of results from the pilot study. Here we focus on pulmonary nodules and asymptomatic coronary artery stenosis. These clinical features were observed in a large number of participants, and the clinical handing and prognosis related to these observations are unclear. They thus posed great challenges for the study in their practical and ethical handling. This chapter describes how we developed procedures to handle these findings based on existing evidence and expert consensus as well as deliberations on ethical issues.

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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Cardiovascular, Epidemiology, Metabolism, Pulmonary, Study design
host publication
Incidental Radiological Findings
series title
Medical Radiology
editor
Weckbach, Sabine
pages
11 pages
publisher
Springer
external identifiers
  • scopus:85019102819
ISSN
09425373
21974187
ISBN
978-3-319-42581-8
978-3-319-42579-5
DOI
10.1007/174_2016_52
language
English
LU publication?
yes
id
371841af-9ddd-4471-b271-359abf42b8e9
date added to LUP
2017-06-02 12:27:31
date last changed
2025-01-07 14:37:38
@inbook{371841af-9ddd-4471-b271-359abf42b8e9,
  abstract     = {{<p>The Swedish CArdioPulmonary bioImage Study (SCAPIS) combines the use of new imaging technologies, large-scale proteomics/metabolomics/genomics, and epidemiological analyses to extensively characterize a Swedish cohort of 30,000 men and women aged between 50 and 64 years. Its main aims are to improve risk prediction and to optimize our ability to study mechanisms of cardiopulmonary diseases. SCAPIS is currently recruiting at six sites in Sweden, and a pilot study was conducted in 2012 to test the feasibility of the comprehensive study protocol. In the planning phase, it was recognized that the detailed phenotyping used in SCAPIS would identify a large number of clinical findings in need of medical attention. This was confirmed by evaluation of results from the pilot study. Here we focus on pulmonary nodules and asymptomatic coronary artery stenosis. These clinical features were observed in a large number of participants, and the clinical handing and prognosis related to these observations are unclear. They thus posed great challenges for the study in their practical and ethical handling. This chapter describes how we developed procedures to handle these findings based on existing evidence and expert consensus as well as deliberations on ethical issues.</p>}},
  author       = {{Johnsson, Åse and Angerås, Oskar and Blomberg, Anders and Erlinge, David and Flinck, Agneta and Janson, Christer and Markstad, Hanna and Persson, Jonas and Persson, H. Lennart and Swahn, Eva and Toren, Kjell and Vikgren, Jenny and Hansson, Mats G. and Bergström, Göran}},
  booktitle    = {{Incidental Radiological Findings}},
  editor       = {{Weckbach, Sabine}},
  isbn         = {{978-3-319-42581-8}},
  issn         = {{09425373}},
  keywords     = {{Cardiovascular; Epidemiology; Metabolism; Pulmonary; Study design}},
  language     = {{eng}},
  pages        = {{91--101}},
  publisher    = {{Springer}},
  series       = {{Medical Radiology}},
  title        = {{Incidental findings and their handling in the Swedish CArdioPulmonary bioimage study (SCAPIS)}},
  url          = {{http://dx.doi.org/10.1007/174_2016_52}},
  doi          = {{10.1007/174_2016_52}},
  year         = {{2017}},
}