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Cardiovascular function in children born very preterm after intrauterine growth restriction with severely abnormal umbilical artery blood flow.

Morsing, Eva LU ; Liuba, Petru LU ; Fellman, Vineta LU ; Marsal, Karel LU and Brodszki, Jana LU (2014) In European Journal of Preventive Cardiology 21(10). p.1257-1266
Abstract
AIMS: Low birthweight has been linked to increased cardiovascular risk in adulthood. We evaluated the effect on cardiovascular outcome of intrauterine growth restriction (IUGR) with abnormal fetal blood flow in children born very preterm. METHODS: Blood pressure, cardiac function and size, diameters, distensibility, and stiffness of the abdominal aorta, carotid, and popliteal arteries, and endothelial function were assessed non-invasively in 7-year-old children (n = 32) born very preterm with IUGR, with birthweight (median, range) 650 g (395-976 g) and gestational age 27 weeks (24-29 weeks). In addition, intima-media thickness was measured in the carotid artery. Controls were matched for gender and age and had birthweight... (More)
AIMS: Low birthweight has been linked to increased cardiovascular risk in adulthood. We evaluated the effect on cardiovascular outcome of intrauterine growth restriction (IUGR) with abnormal fetal blood flow in children born very preterm. METHODS: Blood pressure, cardiac function and size, diameters, distensibility, and stiffness of the abdominal aorta, carotid, and popliteal arteries, and endothelial function were assessed non-invasively in 7-year-old children (n = 32) born very preterm with IUGR, with birthweight (median, range) 650 g (395-976 g) and gestational age 27 weeks (24-29 weeks). In addition, intima-media thickness was measured in the carotid artery. Controls were matched for gender and age and had birthweight appropriate-for-gestational-age (AGA). The study included 32 preterm-AGA children with birthweight 1010 g (660-1790) g and 32 term-AGA children with birthweight 3530 g (3000-4390) g. RESULTS: Preterm-IUGR children had lower microvascular response to acetylcholine, lower aortic stiffness, and higher distensibility compared with the preterm-AGA group (p = 0.019, p = 0.001, and p < 0.001, respectively) and lower carotid intima-media thickness compared with the term-AGA group (p = 0.047). The highest aortic β and lowest distensibility were found in the preterm-AGA group. Height-adjusted systolic blood pressure was higher in the preterm groups than in the term-AGA group (p = 0.018). Cardiac function and size did not differ between the groups. CONCLUSION: IUGR and preterm birth appear to be associated with structural changes in the arterial wall, whereas preterm birth seems to be associated with higher blood pressure. Using conventional echocardiography, we observed no effect of IUGR on cardiac size and function. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
European Journal of Preventive Cardiology
volume
21
issue
10
pages
1257 - 1266
publisher
SAGE Publications Inc.
external identifiers
  • pmid:23613223
  • wos:000342818000008
  • scopus:84907502042
ISSN
2047-4881
DOI
10.1177/2047487313486044
language
English
LU publication?
yes
id
c153b850-bbaf-44f3-b01d-d86ee3986d9c (old id 3733405)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23613223?dopt=Abstract
date added to LUP
2013-05-04 20:36:01
date last changed
2017-06-11 03:16:50
@article{c153b850-bbaf-44f3-b01d-d86ee3986d9c,
  abstract     = {AIMS: Low birthweight has been linked to increased cardiovascular risk in adulthood. We evaluated the effect on cardiovascular outcome of intrauterine growth restriction (IUGR) with abnormal fetal blood flow in children born very preterm. METHODS: Blood pressure, cardiac function and size, diameters, distensibility, and stiffness of the abdominal aorta, carotid, and popliteal arteries, and endothelial function were assessed non-invasively in 7-year-old children (n = 32) born very preterm with IUGR, with birthweight (median, range) 650 g (395-976 g) and gestational age 27 weeks (24-29 weeks). In addition, intima-media thickness was measured in the carotid artery. Controls were matched for gender and age and had birthweight appropriate-for-gestational-age (AGA). The study included 32 preterm-AGA children with birthweight 1010 g (660-1790) g and 32 term-AGA children with birthweight 3530 g (3000-4390) g. RESULTS: Preterm-IUGR children had lower microvascular response to acetylcholine, lower aortic stiffness, and higher distensibility compared with the preterm-AGA group (p = 0.019, p = 0.001, and p &lt; 0.001, respectively) and lower carotid intima-media thickness compared with the term-AGA group (p = 0.047). The highest aortic β and lowest distensibility were found in the preterm-AGA group. Height-adjusted systolic blood pressure was higher in the preterm groups than in the term-AGA group (p = 0.018). Cardiac function and size did not differ between the groups. CONCLUSION: IUGR and preterm birth appear to be associated with structural changes in the arterial wall, whereas preterm birth seems to be associated with higher blood pressure. Using conventional echocardiography, we observed no effect of IUGR on cardiac size and function.},
  author       = {Morsing, Eva and Liuba, Petru and Fellman, Vineta and Marsal, Karel and Brodszki, Jana},
  issn         = {2047-4881},
  language     = {eng},
  number       = {10},
  pages        = {1257--1266},
  publisher    = {SAGE Publications Inc.},
  series       = {European Journal of Preventive Cardiology},
  title        = {Cardiovascular function in children born very preterm after intrauterine growth restriction with severely abnormal umbilical artery blood flow.},
  url          = {http://dx.doi.org/10.1177/2047487313486044},
  volume       = {21},
  year         = {2014},
}