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No Difference in Small or Large Nerve Fiber Function Between Individuals With Normal Glucose Tolerance and Impaired Glucose Tolerance

Pourhamidi, Kaveh ; Dahlin, Lars LU orcid ; Englund, Elisabet LU orcid and Rolandsson, Olov (2013) In Diabetes Care 36(4). p.962-964
Abstract
OBJECTIVE-To assess small and large nerve fiber function in people with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS-Participants were recruited consecutively from a population-based cohort: NGT (n = 39), IGT (n = 29), and T2D (n = 51). Electrophysiological measures included nerve conduction studies and thermal thresholds. Intraepidermal nerve fiber density (IENFD) in skin biopsies was calculated. RESULTS-There was no difference between IGT and NGT in sural nerve conduction, IENFD, and thermal thresholds. IENFD was significantly lower in T2D (median = 2.8 fibers/mm [interquartile range 1.1-4.7 fibers/mm]) than NGT individuals (4.5 fibers/mm [3.4-6.1 fibers/mm]; P... (More)
OBJECTIVE-To assess small and large nerve fiber function in people with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS-Participants were recruited consecutively from a population-based cohort: NGT (n = 39), IGT (n = 29), and T2D (n = 51). Electrophysiological measures included nerve conduction studies and thermal thresholds. Intraepidermal nerve fiber density (IENFD) in skin biopsies was calculated. RESULTS-There was no difference between IGT and NGT in sural nerve conduction, IENFD, and thermal thresholds. IENFD was significantly lower in T2D (median = 2.8 fibers/mm [interquartile range 1.1-4.7 fibers/mm]) than NGT individuals (4.5 fibers/mm [3.4-6.1 fibers/mm]; P < 0.05). T2D participants had poorer nerve conduction and higher heat thresholds than NGT and IGT. CONCLUSIONS-Large and small nerve function in people with IGT did not differ from those with NGT. Our finding does not support the existence of neuropathy in a prediabetic stage. Diabetes Care 36:962-964, 2013 (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
36
issue
4
pages
962 - 964
publisher
American Diabetes Association
external identifiers
  • wos:000316462400045
  • scopus:84875457184
  • pmid:23223347
ISSN
1935-5548
DOI
10.2337/dc12-1331
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hand Surgery Research Group (013241910), Pathology, (Lund) (013030000)
id
d1bd8f5f-3a28-4e80-95b6-a114a1fb627f (old id 3764998)
date added to LUP
2016-04-01 14:07:53
date last changed
2022-03-21 22:16:54
@article{d1bd8f5f-3a28-4e80-95b6-a114a1fb627f,
  abstract     = {{OBJECTIVE-To assess small and large nerve fiber function in people with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS-Participants were recruited consecutively from a population-based cohort: NGT (n = 39), IGT (n = 29), and T2D (n = 51). Electrophysiological measures included nerve conduction studies and thermal thresholds. Intraepidermal nerve fiber density (IENFD) in skin biopsies was calculated. RESULTS-There was no difference between IGT and NGT in sural nerve conduction, IENFD, and thermal thresholds. IENFD was significantly lower in T2D (median = 2.8 fibers/mm [interquartile range 1.1-4.7 fibers/mm]) than NGT individuals (4.5 fibers/mm [3.4-6.1 fibers/mm]; P &lt; 0.05). T2D participants had poorer nerve conduction and higher heat thresholds than NGT and IGT. CONCLUSIONS-Large and small nerve function in people with IGT did not differ from those with NGT. Our finding does not support the existence of neuropathy in a prediabetic stage. Diabetes Care 36:962-964, 2013}},
  author       = {{Pourhamidi, Kaveh and Dahlin, Lars and Englund, Elisabet and Rolandsson, Olov}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{962--964}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{No Difference in Small or Large Nerve Fiber Function Between Individuals With Normal Glucose Tolerance and Impaired Glucose Tolerance}},
  url          = {{https://lup.lub.lu.se/search/files/3802991/4092320.pdf}},
  doi          = {{10.2337/dc12-1331}},
  volume       = {{36}},
  year         = {{2013}},
}