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Thymidine kinase diversity in bacteria

Sandrini, Michael LU ; Clausen, Anders Ranegaard LU ; Munch-Petersen, Birgitte LU and Piskur, Jure LU (2006) In Nucleosides, Nucleotides & Nucleic Acids 25(9-11). p.1153-1158
Abstract
Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pyrimidines, nucleosides, thymidine kinase, deoxyribonucleoside kinase, evolution, nucleic acids precursors
in
Nucleosides, Nucleotides & Nucleic Acids
volume
25
issue
9-11
pages
1153 - 1158
publisher
Taylor & Francis
external identifiers
  • wos:000242019000034
  • scopus:33750436614
ISSN
1525-7770
DOI
10.1080/15257770600894469
language
English
LU publication?
yes
id
2d964cab-f0fe-4e23-a603-eacd7d7b0573 (old id 376864)
date added to LUP
2016-04-01 12:04:46
date last changed
2021-04-13 04:37:10
@article{2d964cab-f0fe-4e23-a603-eacd7d7b0573,
  abstract     = {Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.},
  author       = {Sandrini, Michael and Clausen, Anders Ranegaard and Munch-Petersen, Birgitte and Piskur, Jure},
  issn         = {1525-7770},
  language     = {eng},
  number       = {9-11},
  pages        = {1153--1158},
  publisher    = {Taylor & Francis},
  series       = {Nucleosides, Nucleotides & Nucleic Acids},
  title        = {Thymidine kinase diversity in bacteria},
  url          = {http://dx.doi.org/10.1080/15257770600894469},
  doi          = {10.1080/15257770600894469},
  volume       = {25},
  year         = {2006},
}