Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patients
(2006) In Anticancer research 26(5B). p.3669-3674- Abstract
- Chemokines are chemotactic cytokines that orchestrate leukocyte trafficking in tissues, thus, playing an important role in regulation of immunological processes. The aim of this study was to investigate the association of human papillomavirus (HPV) infection and cervical cancer with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64L The study material consisted of 50 cervical intraepithelial neoplasia (CIN) cases and 50 of age and sampling-date matched controls, 100 invasive cervix cancer cases and 100 of their corresponding matched disease-free controls. Pyrosequencing (TM) was employed to genotype the CCR2-64I polymorphism. CCR5-Delta 32 was genotyped using standard PCR fragment length analysis. The frequencies... (More)
- Chemokines are chemotactic cytokines that orchestrate leukocyte trafficking in tissues, thus, playing an important role in regulation of immunological processes. The aim of this study was to investigate the association of human papillomavirus (HPV) infection and cervical cancer with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64L The study material consisted of 50 cervical intraepithelial neoplasia (CIN) cases and 50 of age and sampling-date matched controls, 100 invasive cervix cancer cases and 100 of their corresponding matched disease-free controls. Pyrosequencing (TM) was employed to genotype the CCR2-64I polymorphism. CCR5-Delta 32 was genotyped using standard PCR fragment length analysis. The frequencies of CCR2 and CCR5 genotypes from 150 patients and 150 healthy controls were representative of the general population according to the Hardy-Weinberg equilibrium analysis. Risk association was computed with conditional logistic regression analysis. HPV-positive individuals with the rare CCR5 Delta 32/Delta 32 genotype have a risk of 4.58 (CI=0.40-52.64, p-valite=0.045) compare to HPV negative group. The Delta-32 mutation on the CCR locus is imperceptibly associated with increased risk of HPV infection. In total, cervical neoplasia was not associated with genetic polymorphism of CCR2 and CCR5. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/378540
- author
- Zheng, Biying ; Wiklund, Fredrik ; Gharizadeh, Baback ; Sadat, Mehdi ; Gambelunghe, Giovanni ; Hallmans, Goran ; Dillner, Joakim LU ; Wallin, Keng-Ling and Ghaderi, Mehran
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cervical neoplasia, chemokine receptor, gene polymorphism, pyrosequencing
- in
- Anticancer research
- volume
- 26
- issue
- 5B
- pages
- 3669 - 3674
- publisher
- International Institute of Cancer Research
- external identifiers
-
- wos:000241707500008
- scopus:33750685971
- ISSN
- 1791-7530
- language
- English
- LU publication?
- yes
- id
- 208b820e-a5c9-479a-a250-cf3d2a865489 (old id 378540)
- alternative location
- http://www.iiar-anticancer.org/research/level3.php?issue=5B&volume=26&page=3669
- date added to LUP
- 2016-04-01 12:21:23
- date last changed
- 2022-01-27 02:37:34
@article{208b820e-a5c9-479a-a250-cf3d2a865489,
abstract = {{Chemokines are chemotactic cytokines that orchestrate leukocyte trafficking in tissues, thus, playing an important role in regulation of immunological processes. The aim of this study was to investigate the association of human papillomavirus (HPV) infection and cervical cancer with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64L The study material consisted of 50 cervical intraepithelial neoplasia (CIN) cases and 50 of age and sampling-date matched controls, 100 invasive cervix cancer cases and 100 of their corresponding matched disease-free controls. Pyrosequencing (TM) was employed to genotype the CCR2-64I polymorphism. CCR5-Delta 32 was genotyped using standard PCR fragment length analysis. The frequencies of CCR2 and CCR5 genotypes from 150 patients and 150 healthy controls were representative of the general population according to the Hardy-Weinberg equilibrium analysis. Risk association was computed with conditional logistic regression analysis. HPV-positive individuals with the rare CCR5 Delta 32/Delta 32 genotype have a risk of 4.58 (CI=0.40-52.64, p-valite=0.045) compare to HPV negative group. The Delta-32 mutation on the CCR locus is imperceptibly associated with increased risk of HPV infection. In total, cervical neoplasia was not associated with genetic polymorphism of CCR2 and CCR5.}},
author = {{Zheng, Biying and Wiklund, Fredrik and Gharizadeh, Baback and Sadat, Mehdi and Gambelunghe, Giovanni and Hallmans, Goran and Dillner, Joakim and Wallin, Keng-Ling and Ghaderi, Mehran}},
issn = {{1791-7530}},
keywords = {{cervical neoplasia; chemokine receptor; gene polymorphism; pyrosequencing}},
language = {{eng}},
number = {{5B}},
pages = {{3669--3674}},
publisher = {{International Institute of Cancer Research}},
series = {{Anticancer research}},
title = {{Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patients}},
url = {{http://www.iiar-anticancer.org/research/level3.php?issue=5B&volume=26&page=3669}},
volume = {{26}},
year = {{2006}},
}