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Magnetic nanosheets : from iron oxide nanocubes to polydopamine embedded 2D clusters and their multi-purpose properties

Mandriota, Giacomo ; Avugadda, Sahitya Kumar ; Sadeghi, Ehsan ; Silvestri, Niccolò ; Marotta, Roberto ; Gavilán, Helena ; Olsson, Ulf LU orcid ; Giannini, Cinzia ; Tsai, Yu Hsin and Samia, Anna Cristina S. , et al. (2025) In Nanoscale Horizons 10(6). p.1140-1158
Abstract

We here develop stable bidimensional magnetic nanoclusters (2D-MNCs) of iron oxide nanocubes (IONCs) arranged in thin nanosheets of closed-packed nanocubes. The assembly occurs by means of a two-step approach: in the first one, the ionic surfactant, sodium dodecyl sulfate (SDS), acts as a transient water transfer agent and as 2D clustering agent to induce formation of a monolayer of nanocubes arranged in thin nanosheets. Next, the addition of dopamine followed by solution basification, induces the in situ polymerization of dopamine with a tunable shell tickness depending on the dopamine amount, which helps to compact the clusters and ensures the long term water stability of the clusters. TEM, cryo-EM, and SAXS techniques helped to... (More)

We here develop stable bidimensional magnetic nanoclusters (2D-MNCs) of iron oxide nanocubes (IONCs) arranged in thin nanosheets of closed-packed nanocubes. The assembly occurs by means of a two-step approach: in the first one, the ionic surfactant, sodium dodecyl sulfate (SDS), acts as a transient water transfer agent and as 2D clustering agent to induce formation of a monolayer of nanocubes arranged in thin nanosheets. Next, the addition of dopamine followed by solution basification, induces the in situ polymerization of dopamine with a tunable shell tickness depending on the dopamine amount, which helps to compact the clusters and ensures the long term water stability of the clusters. TEM, cryo-EM, and SAXS techniques helped to reveal structural features of the 2D-clusters. The pH-dependent degradation properties of polydopamine, enable to disassemble the clusters in acidic tumour microenviroment leading to a four-fold increase in the magnetic particle imaging signal and a concomitant increase of the magnetic heat losses of these clusters, makes them appealing in magnetic hyperthermia, while the shortening of T2 relaxation time suggests their use as contrast in magnetic resonance imaging. Finally, with crystal violet dye, used as drug molecule, the feasibility to release payloads pre-encapsulated with the polydopamine polymer shell has been also shown.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nanoscale Horizons
volume
10
issue
6
pages
19 pages
publisher
Royal Society of Chemistry
external identifiers
  • pmid:40191967
  • scopus:105002796760
ISSN
2055-6756
DOI
10.1039/d4nh00566j
language
English
LU publication?
yes
id
3790c7b8-a740-4777-8279-31a3b80888f6
date added to LUP
2025-08-28 11:45:51
date last changed
2025-10-09 15:41:58
@article{3790c7b8-a740-4777-8279-31a3b80888f6,
  abstract     = {{<p>We here develop stable bidimensional magnetic nanoclusters (2D-MNCs) of iron oxide nanocubes (IONCs) arranged in thin nanosheets of closed-packed nanocubes. The assembly occurs by means of a two-step approach: in the first one, the ionic surfactant, sodium dodecyl sulfate (SDS), acts as a transient water transfer agent and as 2D clustering agent to induce formation of a monolayer of nanocubes arranged in thin nanosheets. Next, the addition of dopamine followed by solution basification, induces the in situ polymerization of dopamine with a tunable shell tickness depending on the dopamine amount, which helps to compact the clusters and ensures the long term water stability of the clusters. TEM, cryo-EM, and SAXS techniques helped to reveal structural features of the 2D-clusters. The pH-dependent degradation properties of polydopamine, enable to disassemble the clusters in acidic tumour microenviroment leading to a four-fold increase in the magnetic particle imaging signal and a concomitant increase of the magnetic heat losses of these clusters, makes them appealing in magnetic hyperthermia, while the shortening of T<sub>2</sub> relaxation time suggests their use as contrast in magnetic resonance imaging. Finally, with crystal violet dye, used as drug molecule, the feasibility to release payloads pre-encapsulated with the polydopamine polymer shell has been also shown.</p>}},
  author       = {{Mandriota, Giacomo and Avugadda, Sahitya Kumar and Sadeghi, Ehsan and Silvestri, Niccolò and Marotta, Roberto and Gavilán, Helena and Olsson, Ulf and Giannini, Cinzia and Tsai, Yu Hsin and Samia, Anna Cristina S. and Pellegrino, Teresa}},
  issn         = {{2055-6756}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1140--1158}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Nanoscale Horizons}},
  title        = {{Magnetic nanosheets : from iron oxide nanocubes to polydopamine embedded 2D clusters and their multi-purpose properties}},
  url          = {{http://dx.doi.org/10.1039/d4nh00566j}},
  doi          = {{10.1039/d4nh00566j}},
  volume       = {{10}},
  year         = {{2025}},
}