Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

NT-proBNP and metabolic risk factors in a bi-ethnic cohort : the Ambulatory Blood Pressure in African prospective cohort study

Jujić, Amra LU ; Melander, Olle LU orcid ; Nilsson, Peter M LU ; Malan, Leoné ; Fedorowski, Artur LU orcid and Magnusson, Martin LU orcid (2020) In Cardiovascular Journal of Africa 31(6). p.291-297
Abstract

BACKGROUND: We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort.

METHODS: Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teachers (black African, n = 194; Caucasian, n = 203).

RESULTS: Each one standard deviation increment of NT-proBNP was significantly inversely associated with body mass index ( β -1.01), glycated haemoglobin ( β -0.14 %), waist circumference (β -1.82), HOMA-IR (β -0.47), insulin (β -1.66) and triglyceride levels (β -0.04). Each one... (More)

BACKGROUND: We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort.

METHODS: Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teachers (black African, n = 194; Caucasian, n = 203).

RESULTS: Each one standard deviation increment of NT-proBNP was significantly inversely associated with body mass index ( β -1.01), glycated haemoglobin ( β -0.14 %), waist circumference (β -1.82), HOMA-IR (β -0.47), insulin (β -1.66) and triglyceride levels (β -0.04). Each one standard deviation increment of NT-proBNP was also associated with reduced odds of incident diabetes, and subjects within the highest quartile of NT-proBNP were at lowest risk (OR: 0.24; 95% CI: 0.06-0.96; p = 0.041).

CONCLUSIONS: In the SABPA cohort, Africans and Caucasians had similar NT-proBNP levels; however, the associations for Africans were stronger. Those findings suggest that BNP may affect the propensity for metabolic disturbances differently in Africans and Caucasians.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cardiovascular Journal of Africa
volume
31
issue
6
pages
7 pages
publisher
Clinics Cardive Publishing (pty) Ltd
external identifiers
  • pmid:33180090
  • scopus:85098846723
ISSN
1995-1892
DOI
10.5830/CVJA-2020-017
language
English
LU publication?
yes
id
37e70f0c-0bf7-4ff5-8a51-6e95583c1d4d
date added to LUP
2020-11-13 09:50:21
date last changed
2024-04-03 18:05:23
@article{37e70f0c-0bf7-4ff5-8a51-6e95583c1d4d,
  abstract     = {{<p>BACKGROUND: We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort.</p><p>METHODS: Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teachers (black African, n = 194; Caucasian, n = 203).</p><p>RESULTS: Each one standard deviation increment of NT-proBNP was significantly inversely associated with body mass index ( β -1.01), glycated haemoglobin ( β -0.14 %), waist circumference (β -1.82), HOMA-IR (β -0.47), insulin (β -1.66) and triglyceride levels (β -0.04). Each one standard deviation increment of NT-proBNP was also associated with reduced odds of incident diabetes, and subjects within the highest quartile of NT-proBNP were at lowest risk (OR: 0.24; 95% CI: 0.06-0.96; p = 0.041).</p><p>CONCLUSIONS: In the SABPA cohort, Africans and Caucasians had similar NT-proBNP levels; however, the associations for Africans were stronger. Those findings suggest that BNP may affect the propensity for metabolic disturbances differently in Africans and Caucasians.</p>}},
  author       = {{Jujić, Amra and Melander, Olle and Nilsson, Peter M and Malan, Leoné and Fedorowski, Artur and Magnusson, Martin}},
  issn         = {{1995-1892}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{6}},
  pages        = {{291--297}},
  publisher    = {{Clinics Cardive Publishing (pty) Ltd}},
  series       = {{Cardiovascular Journal of Africa}},
  title        = {{NT-proBNP and metabolic risk factors in a bi-ethnic cohort : the Ambulatory Blood Pressure in African prospective cohort study}},
  url          = {{http://dx.doi.org/10.5830/CVJA-2020-017}},
  doi          = {{10.5830/CVJA-2020-017}},
  volume       = {{31}},
  year         = {{2020}},
}