NT-proBNP and metabolic risk factors in a bi-ethnic cohort : the Ambulatory Blood Pressure in African prospective cohort study
(2020) In Cardiovascular Journal of Africa 31(6). p.291-297- Abstract
BACKGROUND: We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort.
METHODS: Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teachers (black African, n = 194; Caucasian, n = 203).
RESULTS: Each one standard deviation increment of NT-proBNP was significantly inversely associated with body mass index ( β -1.01), glycated haemoglobin ( β -0.14 %), waist circumference (β -1.82), HOMA-IR (β -0.47), insulin (β -1.66) and triglyceride levels (β -0.04). Each one... (More)
BACKGROUND: We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort.
METHODS: Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teachers (black African, n = 194; Caucasian, n = 203).
RESULTS: Each one standard deviation increment of NT-proBNP was significantly inversely associated with body mass index ( β -1.01), glycated haemoglobin ( β -0.14 %), waist circumference (β -1.82), HOMA-IR (β -0.47), insulin (β -1.66) and triglyceride levels (β -0.04). Each one standard deviation increment of NT-proBNP was also associated with reduced odds of incident diabetes, and subjects within the highest quartile of NT-proBNP were at lowest risk (OR: 0.24; 95% CI: 0.06-0.96; p = 0.041).
CONCLUSIONS: In the SABPA cohort, Africans and Caucasians had similar NT-proBNP levels; however, the associations for Africans were stronger. Those findings suggest that BNP may affect the propensity for metabolic disturbances differently in Africans and Caucasians.
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- author
- Jujić, Amra LU ; Melander, Olle LU ; Nilsson, Peter M LU ; Malan, Leoné ; Fedorowski, Artur LU and Magnusson, Martin LU
- organization
- publishing date
- 2020-11-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cardiovascular Journal of Africa
- volume
- 31
- issue
- 6
- pages
- 7 pages
- publisher
- Clinics Cardive Publishing (pty) Ltd
- external identifiers
-
- pmid:33180090
- scopus:85098846723
- ISSN
- 1995-1892
- DOI
- 10.5830/CVJA-2020-017
- language
- English
- LU publication?
- yes
- id
- 37e70f0c-0bf7-4ff5-8a51-6e95583c1d4d
- date added to LUP
- 2020-11-13 09:50:21
- date last changed
- 2024-04-03 18:05:23
@article{37e70f0c-0bf7-4ff5-8a51-6e95583c1d4d, abstract = {{<p>BACKGROUND: We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort.</p><p>METHODS: Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teachers (black African, n = 194; Caucasian, n = 203).</p><p>RESULTS: Each one standard deviation increment of NT-proBNP was significantly inversely associated with body mass index ( β -1.01), glycated haemoglobin ( β -0.14 %), waist circumference (β -1.82), HOMA-IR (β -0.47), insulin (β -1.66) and triglyceride levels (β -0.04). Each one standard deviation increment of NT-proBNP was also associated with reduced odds of incident diabetes, and subjects within the highest quartile of NT-proBNP were at lowest risk (OR: 0.24; 95% CI: 0.06-0.96; p = 0.041).</p><p>CONCLUSIONS: In the SABPA cohort, Africans and Caucasians had similar NT-proBNP levels; however, the associations for Africans were stronger. Those findings suggest that BNP may affect the propensity for metabolic disturbances differently in Africans and Caucasians.</p>}}, author = {{Jujić, Amra and Melander, Olle and Nilsson, Peter M and Malan, Leoné and Fedorowski, Artur and Magnusson, Martin}}, issn = {{1995-1892}}, language = {{eng}}, month = {{11}}, number = {{6}}, pages = {{291--297}}, publisher = {{Clinics Cardive Publishing (pty) Ltd}}, series = {{Cardiovascular Journal of Africa}}, title = {{NT-proBNP and metabolic risk factors in a bi-ethnic cohort : the Ambulatory Blood Pressure in African prospective cohort study}}, url = {{http://dx.doi.org/10.5830/CVJA-2020-017}}, doi = {{10.5830/CVJA-2020-017}}, volume = {{31}}, year = {{2020}}, }