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The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate

Simonsen, Ole LU ; Grubb, Anders LU orcid and Thysell, Hans LU (1985) In Scandinavian Journal of Clinical & Laboratory Investigation 45(2). p.97-101
Abstract
The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular... (More)
The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
45
issue
2
pages
97 - 101
publisher
Informa Healthcare
external identifiers
  • pmid:3923607
  • scopus:0021964955
ISSN
1502-7686
DOI
10.3109/00365518509160980
language
English
LU publication?
yes
id
37eb603a-a152-43e4-a6b4-242b4147e05e
date added to LUP
2018-11-16 16:35:39
date last changed
2021-11-08 04:00:14
@article{37eb603a-a152-43e4-a6b4-242b4147e05e,
  abstract     = {{The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin.}},
  author       = {{Simonsen, Ole and Grubb, Anders and Thysell, Hans}},
  issn         = {{1502-7686}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{97--101}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
  title        = {{The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate}},
  url          = {{http://dx.doi.org/10.3109/00365518509160980}},
  doi          = {{10.3109/00365518509160980}},
  volume       = {{45}},
  year         = {{1985}},
}