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STUDIES OF EFFECTS OF GSM-900 MICROWAVE EXPOSURE ON DNA ”MICRONUCLEUS” FORMATION IN MICE

Gravé, Jan; Abrahamsson Zetterberg, Lilianne; Persson, Bertil R LU and Salford, Leif LU (2012) In Acta Scientiarum Lundensia 2012(002). p.1-15
Abstract
Possible genotoxic effects of microwave exposure from GSM-900 mobile telephones have investigated with in vivo micronucleus assay of mouse erythrocytes from CBA mice and GFAP knockout mice. No significant change in the frequency of erythrocytes with micronuclei neither in the young (polychromatic PCE) or mature (normichromatic NCE) erythrocytes. There is, however, a tendency but not significant to increased MPCE in female mice after 35 days of exposure. There is a marked tendency to lower PCE-fraction in the exposed groups. When male and female is studied separately there is no significant difference. However, if the values are normalised to eliminate the sex-difference there is a significant lower fraction in the exposed mice. Another... (More)
Possible genotoxic effects of microwave exposure from GSM-900 mobile telephones have investigated with in vivo micronucleus assay of mouse erythrocytes from CBA mice and GFAP knockout mice. No significant change in the frequency of erythrocytes with micronuclei neither in the young (polychromatic PCE) or mature (normichromatic NCE) erythrocytes. There is, however, a tendency but not significant to increased MPCE in female mice after 35 days of exposure. There is a marked tendency to lower PCE-fraction in the exposed groups. When male and female is studied separately there is no significant difference. However, if the values are normalised to eliminate the sex-difference there is a significant lower fraction in the exposed mice. Another observation is lower weight of the exposed male.

If normalised data for both sexes are pooled there is an almost significant difference (95% level) in weight. We found a less pronounced difference in the CBE mice than in the GFAP experiment. Thus genotype might play a role in microwave exposure. Differences in exposure time and number of controls in GFAP and CBA experiment might influence the results. We observe a moderate decrease of formation of new erythrocytes in the exposed animals. This

might fit the tendency of lower weight in the exposed animals and might indicate a general decreased cell-proliferation in the exposed animals. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
GSM-900, mobile telephones, microwave, erythrocytes (E), polychromatic (PCE) or mature normichromatic (NCE), micronuclei, CBA mice, GFAP knock-out mice
in
Acta Scientiarum Lundensia
volume
2012
issue
002
pages
1 - 15
publisher
Bertil RR Persson, Medical Radiation Physics, 22185 Lund, Sweden
ISSN
1651-5013
language
English
LU publication?
yes
id
9fcd7391-f03e-43b1-99ab-dbc4ddc8fca4 (old id 3802800)
date added to LUP
2015-05-27 12:24:26
date last changed
2016-04-15 21:36:49
@article{9fcd7391-f03e-43b1-99ab-dbc4ddc8fca4,
  abstract     = {Possible genotoxic effects of microwave exposure from GSM-900 mobile telephones have investigated with in vivo micronucleus assay of mouse erythrocytes from CBA mice and GFAP knockout mice. No significant change in the frequency of erythrocytes with micronuclei neither in the young (polychromatic PCE) or mature (normichromatic NCE) erythrocytes. There is, however, a tendency but not significant to increased MPCE in female mice after 35 days of exposure. There is a marked tendency to lower PCE-fraction in the exposed groups. When male and female is studied separately there is no significant difference. However, if the values are normalised to eliminate the sex-difference there is a significant lower fraction in the exposed mice. Another observation is lower weight of the exposed male.<br/><br>
If normalised data for both sexes are pooled there is an almost significant difference (95% level) in weight. We found a less pronounced difference in the CBE mice than in the GFAP experiment. Thus genotype might play a role in microwave exposure. Differences in exposure time and number of controls in GFAP and CBA experiment might influence the results. We observe a moderate decrease of formation of new erythrocytes in the exposed animals. This<br/><br>
might fit the tendency of lower weight in the exposed animals and might indicate a general decreased cell-proliferation in the exposed animals.},
  author       = {Gravé, Jan and Abrahamsson Zetterberg, Lilianne and Persson, Bertil R and Salford, Leif},
  issn         = {1651-5013},
  keyword      = {GSM-900,mobile telephones,microwave,erythrocytes (E),polychromatic (PCE) or mature normichromatic (NCE),micronuclei,CBA mice,GFAP knock-out mice},
  language     = {eng},
  number       = {002},
  pages        = {1--15},
  publisher    = {Bertil RR Persson, Medical Radiation Physics, 22185 Lund, Sweden},
  series       = {Acta Scientiarum Lundensia},
  title        = {STUDIES OF EFFECTS OF GSM-900 MICROWAVE EXPOSURE ON DNA ”MICRONUCLEUS” FORMATION IN MICE},
  volume       = {2012},
  year         = {2012},
}