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Short-term Outcomes for Open and Laparoscopic Midline Incisional Hernia Repair: A Randomized Multicenter Controlled Trial: The ProLOVE (Prospective Randomized Trial on Open Versus Laparoscopic Operation of Ventral Eventrations) Trial.

Rogmark, Peder LU ; Petersson, Ulf LU ; Bringman, Sven; Eklund, Arne; Ezra, Emmanuel; Sevonius, Dan LU ; Smedberg, Sam; Osterberg, Johanna and Montgomery, Agneta LU (2013) In Annals of Surgery
Abstract
OBJECTIVE:: The aim of the trial was to compare laparoscopic technique with open technique regarding short-term pain, quality of life (QoL), recovery, and complications. BACKGROUND:: Laparoscopic and open techniques for incisional hernia repair are recognized treatment options with pros and cons. METHODS:: Patients from 7 centers with a midline incisional hernia of a maximum width of 10 cm were randomized to either laparoscopic (LR) or open sublay (OR) mesh repair. Primary end point was pain at 3 weeks, measured as the bodily pain subscale of Short Form-36 (SF-36). Secondary end points were complications registered by type and severity (the Clavien-Dindo classification), movement restrictions, fatigue, time to full recovery, and QoL up to... (More)
OBJECTIVE:: The aim of the trial was to compare laparoscopic technique with open technique regarding short-term pain, quality of life (QoL), recovery, and complications. BACKGROUND:: Laparoscopic and open techniques for incisional hernia repair are recognized treatment options with pros and cons. METHODS:: Patients from 7 centers with a midline incisional hernia of a maximum width of 10 cm were randomized to either laparoscopic (LR) or open sublay (OR) mesh repair. Primary end point was pain at 3 weeks, measured as the bodily pain subscale of Short Form-36 (SF-36). Secondary end points were complications registered by type and severity (the Clavien-Dindo classification), movement restrictions, fatigue, time to full recovery, and QoL up to 8 weeks. RESULTS:: Patients were recruited between October 2005 and November 2009. Of 157 randomized patients, 133 received intervention: 64 LR and 69 OR. Measurements of pain did not differ, nor did movement restriction and postoperative fatigue. SF-36 subscales favored the LR group: physical function (P < 0.001), role physical (P < 0.012), mental health (P < 0.022), and physical composite score (P < 0.009). Surgical site infections were 17 in the OR group compared with 1 in the LR group (P < 0.001). The severity of complications did not differ between the groups (P < 0.213). CONCLUSIONS:: Postoperative pain or recovery at 3 weeks after repair of midline incisional hernias does not differ between LR and OR, but the LR results in better physical function and less surgical site infections than the OR does. (ClinicalTrials.gov Identifier: NCT00472537). (Less)
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Contribution to journal
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published
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in
Annals of Surgery
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:23629524
  • wos:000330460400015
  • scopus:84879091716
ISSN
1528-1140
DOI
10.1097/SLA.0b013e31828fe1b2
language
English
LU publication?
yes
id
4d388b61-d49a-4bcd-86fc-cc6000b3b147 (old id 3805223)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23629524?dopt=Abstract
date added to LUP
2013-06-03 15:22:43
date last changed
2018-04-08 04:32:40
@article{4d388b61-d49a-4bcd-86fc-cc6000b3b147,
  abstract     = {OBJECTIVE:: The aim of the trial was to compare laparoscopic technique with open technique regarding short-term pain, quality of life (QoL), recovery, and complications. BACKGROUND:: Laparoscopic and open techniques for incisional hernia repair are recognized treatment options with pros and cons. METHODS:: Patients from 7 centers with a midline incisional hernia of a maximum width of 10 cm were randomized to either laparoscopic (LR) or open sublay (OR) mesh repair. Primary end point was pain at 3 weeks, measured as the bodily pain subscale of Short Form-36 (SF-36). Secondary end points were complications registered by type and severity (the Clavien-Dindo classification), movement restrictions, fatigue, time to full recovery, and QoL up to 8 weeks. RESULTS:: Patients were recruited between October 2005 and November 2009. Of 157 randomized patients, 133 received intervention: 64 LR and 69 OR. Measurements of pain did not differ, nor did movement restriction and postoperative fatigue. SF-36 subscales favored the LR group: physical function (P &lt; 0.001), role physical (P &lt; 0.012), mental health (P &lt; 0.022), and physical composite score (P &lt; 0.009). Surgical site infections were 17 in the OR group compared with 1 in the LR group (P &lt; 0.001). The severity of complications did not differ between the groups (P &lt; 0.213). CONCLUSIONS:: Postoperative pain or recovery at 3 weeks after repair of midline incisional hernias does not differ between LR and OR, but the LR results in better physical function and less surgical site infections than the OR does. (ClinicalTrials.gov Identifier: NCT00472537).},
  author       = {Rogmark, Peder and Petersson, Ulf and Bringman, Sven and Eklund, Arne and Ezra, Emmanuel and Sevonius, Dan and Smedberg, Sam and Osterberg, Johanna and Montgomery, Agneta},
  issn         = {1528-1140},
  language     = {eng},
  month        = {04},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Annals of Surgery},
  title        = {Short-term Outcomes for Open and Laparoscopic Midline Incisional Hernia Repair: A Randomized Multicenter Controlled Trial: The ProLOVE (Prospective Randomized Trial on Open Versus Laparoscopic Operation of Ventral Eventrations) Trial.},
  url          = {http://dx.doi.org/10.1097/SLA.0b013e31828fe1b2},
  year         = {2013},
}