Sustained norepinephrine contraction in the rat portal vein is lost when Ca(2+) is replaced with Sr(2+).
(2002) In American Journal of Physiology: Cell Physiology 282(4). p.845-852- Abstract
- Agonist-induced activation of smooth muscle involves a rise in intracellular Ca(2+) concentration and sensitization of myosin light chain phosphorylation to Ca(2+). Sr(2+) can enter through Ca(2+) channels, be sequestered and released from sarcoplasmic reticulum, and replace Ca(2+) in activation of myosin light chain phosphorylation. Sr(2+) cannot replace Ca(2+) in facilitation of agonist-activated Ca(2+)-dependent nonselective cation channels. It is not known whether Sr(2+) can replace Ca(2+) in small G protein-mediated sensitization of phosphorylation. To explore mechanisms involved in alpha-receptor-activated contractions in smooth muscle, effects of replacing Ca(2+) with Sr(2+) were examined in rat portal vein. Norepinephrine (NE) at
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/106292
- author
- Bonnevier, Johan LU ; Malmqvist, Ulf LU ; Sonntag, Dagmar ; Schroeter, Mechthild ; Nilsson, Holger ; Pfitzer, Gabriele and Arner, Anders LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Smooth, Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology, Muscle, Vascular/metabolism, Norepinephrine/*pharmacology, Portal Vein/*metabolism, Potassium/pharmacology, Rats, Sprague-Dawley, Support, Strontium/*pharmacokinetics, Non-U.S. Gov't, Vasoconstrictor Agents/*pharmacology, Vasoconstriction/drug effects/physiology, Female, Calcium/*pharmacokinetics, Animal
- in
- American Journal of Physiology: Cell Physiology
- volume
- 282
- issue
- 4
- pages
- 845 - 852
- publisher
- American Physiological Society
- external identifiers
-
- pmid:11880273
- wos:000174231300021
- scopus:0036080597
- ISSN
- 1522-1563
- DOI
- 10.1152/ajpcell.00191.2001
- language
- English
- LU publication?
- yes
- id
- 385b97c7-8c49-4f43-bd98-e73458d5dc8d (old id 106292)
- alternative location
- http://ajpcell.physiology.org/cgi/content/abstract/282/4/C845
- date added to LUP
- 2016-04-01 16:55:33
- date last changed
- 2022-01-28 23:06:37
@article{385b97c7-8c49-4f43-bd98-e73458d5dc8d,
abstract = {{Agonist-induced activation of smooth muscle involves a rise in intracellular Ca(2+) concentration and sensitization of myosin light chain phosphorylation to Ca(2+). Sr(2+) can enter through Ca(2+) channels, be sequestered and released from sarcoplasmic reticulum, and replace Ca(2+) in activation of myosin light chain phosphorylation. Sr(2+) cannot replace Ca(2+) in facilitation of agonist-activated Ca(2+)-dependent nonselective cation channels. It is not known whether Sr(2+) can replace Ca(2+) in small G protein-mediated sensitization of phosphorylation. To explore mechanisms involved in alpha-receptor-activated contractions in smooth muscle, effects of replacing Ca(2+) with Sr(2+) were examined in rat portal vein. Norepinephrine (NE) at}},
author = {{Bonnevier, Johan and Malmqvist, Ulf and Sonntag, Dagmar and Schroeter, Mechthild and Nilsson, Holger and Pfitzer, Gabriele and Arner, Anders}},
issn = {{1522-1563}},
keywords = {{Smooth; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology; Muscle; Vascular/metabolism; Norepinephrine/*pharmacology; Portal Vein/*metabolism; Potassium/pharmacology; Rats; Sprague-Dawley; Support; Strontium/*pharmacokinetics; Non-U.S. Gov't; Vasoconstrictor Agents/*pharmacology; Vasoconstriction/drug effects/physiology; Female; Calcium/*pharmacokinetics; Animal}},
language = {{eng}},
number = {{4}},
pages = {{845--852}},
publisher = {{American Physiological Society}},
series = {{American Journal of Physiology: Cell Physiology}},
title = {{Sustained norepinephrine contraction in the rat portal vein is lost when Ca(2+) is replaced with Sr(2+).}},
url = {{http://dx.doi.org/10.1152/ajpcell.00191.2001}},
doi = {{10.1152/ajpcell.00191.2001}},
volume = {{282}},
year = {{2002}},
}