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Coxsackievirus and adenovirus receptor expression in non-malignant lung tissues and clinical lung cancers

Wang, Yong ; Wang, Shizhong ; Bao, Yongyi ; Ni, Cheng ; Guan, Naifu ; Zhao, Jianzhong ; Salford, Leif LU ; Widegren, Bengt LU and Fan, Xiaolong LU (2006) In Journal of Molecular Histology 37(3-4). p.153-160
Abstract
Adenoviral vector mediated gene delivery has been applied in clinical trials and mechanistic studies to explore new treatment approaches for lung cancers. The expression of coxsackievirus adenovirus receptor (CAR), the primary receptor for the most commonly used adenovirus serotype 5 (Ad5)-based vectors, predominantly determines the permissiveness of lung cancer cells. CAR expression is also suggested to modulate tumor cell proliferation capacity. Here, we studied CAR expression in archival lung cancer specimens by using well-characterized CAR 72 antibodies. High levels of CAR expression were observed in most of the 32 cases of squamous cell carcinoma lung cancers and in all the five cases of small cell lung cancers investigated. In... (More)
Adenoviral vector mediated gene delivery has been applied in clinical trials and mechanistic studies to explore new treatment approaches for lung cancers. The expression of coxsackievirus adenovirus receptor (CAR), the primary receptor for the most commonly used adenovirus serotype 5 (Ad5)-based vectors, predominantly determines the permissiveness of lung cancer cells. CAR expression is also suggested to modulate tumor cell proliferation capacity. Here, we studied CAR expression in archival lung cancer specimens by using well-characterized CAR 72 antibodies. High levels of CAR expression were observed in most of the 32 cases of squamous cell carcinoma lung cancers and in all the five cases of small cell lung cancers investigated. In contrast, high levels of CAR expression were detected only in 6 of 22 adenocarcinoma lung cancers. The relative levels of CAR expression did not correlate with the pathologic grade in lung cancers, and was thus inconsistent with a role of modulating cancer cell proliferation. Of note, CAR expression was not detected in non-malignant alveolar cells. Our data suggest a preferred utility of Ad5 vector mediated gene delivery to squamous cell carcinoma lung cancers, small cell lung cancers, but not to the majority of adenocarcinoma lung cancers. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CAR, recombinant adenoviral vector, lung cancer
in
Journal of Molecular Histology
volume
37
issue
3-4
pages
153 - 160
publisher
Springer
external identifiers
  • wos:000241554200007
  • scopus:33749580537
  • pmid:17031523
ISSN
1567-2379
DOI
10.1007/s10735-006-9055-4
language
English
LU publication?
yes
id
525acb44-db0e-40a1-b52f-96cda9550ecb (old id 386694)
date added to LUP
2016-04-01 11:54:07
date last changed
2021-09-22 04:13:50
@article{525acb44-db0e-40a1-b52f-96cda9550ecb,
  abstract     = {Adenoviral vector mediated gene delivery has been applied in clinical trials and mechanistic studies to explore new treatment approaches for lung cancers. The expression of coxsackievirus adenovirus receptor (CAR), the primary receptor for the most commonly used adenovirus serotype 5 (Ad5)-based vectors, predominantly determines the permissiveness of lung cancer cells. CAR expression is also suggested to modulate tumor cell proliferation capacity. Here, we studied CAR expression in archival lung cancer specimens by using well-characterized CAR 72 antibodies. High levels of CAR expression were observed in most of the 32 cases of squamous cell carcinoma lung cancers and in all the five cases of small cell lung cancers investigated. In contrast, high levels of CAR expression were detected only in 6 of 22 adenocarcinoma lung cancers. The relative levels of CAR expression did not correlate with the pathologic grade in lung cancers, and was thus inconsistent with a role of modulating cancer cell proliferation. Of note, CAR expression was not detected in non-malignant alveolar cells. Our data suggest a preferred utility of Ad5 vector mediated gene delivery to squamous cell carcinoma lung cancers, small cell lung cancers, but not to the majority of adenocarcinoma lung cancers.},
  author       = {Wang, Yong and Wang, Shizhong and Bao, Yongyi and Ni, Cheng and Guan, Naifu and Zhao, Jianzhong and Salford, Leif and Widegren, Bengt and Fan, Xiaolong},
  issn         = {1567-2379},
  language     = {eng},
  number       = {3-4},
  pages        = {153--160},
  publisher    = {Springer},
  series       = {Journal of Molecular Histology},
  title        = {Coxsackievirus and adenovirus receptor expression in non-malignant lung tissues and clinical lung cancers},
  url          = {http://dx.doi.org/10.1007/s10735-006-9055-4},
  doi          = {10.1007/s10735-006-9055-4},
  volume       = {37},
  year         = {2006},
}