Novel aspects of vitamin C: how important is glypican-1 recycling?
(2007) In Trends in Molecular Medicine 13(4). p.143-149- Abstract
- The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/166752
- author
- Fransson, Lars-Åke LU and Mani, Katrin LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Molecular Medicine
- volume
- 13
- issue
- 4
- pages
- 143 - 149
- publisher
- Elsevier
- external identifiers
-
- wos:000246124000002
- scopus:34047097248
- ISSN
- 1471-4914
- DOI
- 10.1016/j.molmed.2007.02.005
- language
- English
- LU publication?
- yes
- id
- 3898d0d4-0e85-48b4-ba3e-d91a399de8eb (old id 166752)
- date added to LUP
- 2016-04-01 15:39:04
- date last changed
- 2023-09-04 04:45:27
@article{3898d0d4-0e85-48b4-ba3e-d91a399de8eb, abstract = {{The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.}}, author = {{Fransson, Lars-Åke and Mani, Katrin}}, issn = {{1471-4914}}, language = {{eng}}, number = {{4}}, pages = {{143--149}}, publisher = {{Elsevier}}, series = {{Trends in Molecular Medicine}}, title = {{Novel aspects of vitamin C: how important is glypican-1 recycling?}}, url = {{https://lup.lub.lu.se/search/files/4440891/625904.pdf}}, doi = {{10.1016/j.molmed.2007.02.005}}, volume = {{13}}, year = {{2007}}, }