Analysis of X chromosome inactivation in autism spectrum disorders
(2008) In American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(6). p.830-835- Abstract
- Autism spectrum disorders (ASD) are complex genetic disorders more frequently observed in males. Skewed X chromosome inactivation (XCI) is observed in heterozygous females carrying gene mutations involved in several X-linked syndromes. In this study, we aimed to estimate the role of X-linked genes in ASD susceptibility by ascertaining the XCI pattern in a sample of 543 informative mothers of children with ASD and in a sample of 163 affected girls. The XCI pattern was also determined in two control groups (144 adult females and 40 young females) with a similar age distribution to the mothers sample and affected girls sample, respectively. We observed no significant excess of skewed XCI in families with ASD. Interestingly, two mothers and... (More)
- Autism spectrum disorders (ASD) are complex genetic disorders more frequently observed in males. Skewed X chromosome inactivation (XCI) is observed in heterozygous females carrying gene mutations involved in several X-linked syndromes. In this study, we aimed to estimate the role of X-linked genes in ASD susceptibility by ascertaining the XCI pattern in a sample of 543 informative mothers of children with ASD and in a sample of 163 affected girls. The XCI pattern was also determined in two control groups (144 adult females and 40 young females) with a similar age distribution to the mothers sample and affected girls sample, respectively. We observed no significant excess of skewed XCI in families with ASD. Interestingly, two mothers and one girl carrying known mutations in X-linked genes (NLGN3, ATRX, MECP2) showed highly skewed XCI, suggesting that ascertainment of XCI could reveal families with X-linked mutations. Linkage analysis was carried out in the subgroup of multiplex families with skewed XCI (80:20) and a modest increased allele sharing was obtained in the Xq27-Xq28 region, with a peak Z-score of 1.75 close to rs719489. In summary, our results suggest that there is no major X-linked gene subject to XCI and expressed in blood cells conferring susceptibility to ASD. However, the possibility that rare mutations in X-linked genes could contribute to ASD cannot be excluded. We propose that the XCI profile could be a useful criteria to prioritize families for mutation screening of X-linked candidate genes. (Less)
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https://lup.lub.lu.se/record/1439947
- author
- author collaboration
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- autistic disorder skewed X-inactivation, linkage study, X-linked mutation
- in
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- volume
- 147B
- issue
- 6
- pages
- 830 - 835
- publisher
- International Society of Psychiatric Genetics
- external identifiers
-
- scopus:51449112549
- pmid:18361425
- ISSN
- 1552-4841
- DOI
- 10.1002/ajmg.b.30688
- language
- English
- LU publication?
- no
- id
- 38aa1136-b46d-4c0d-a1b8-1484d0710ff4 (old id 1439947)
- date added to LUP
- 2016-04-01 12:06:30
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- 2022-01-26 22:57:22
@article{38aa1136-b46d-4c0d-a1b8-1484d0710ff4, abstract = {{Autism spectrum disorders (ASD) are complex genetic disorders more frequently observed in males. Skewed X chromosome inactivation (XCI) is observed in heterozygous females carrying gene mutations involved in several X-linked syndromes. In this study, we aimed to estimate the role of X-linked genes in ASD susceptibility by ascertaining the XCI pattern in a sample of 543 informative mothers of children with ASD and in a sample of 163 affected girls. The XCI pattern was also determined in two control groups (144 adult females and 40 young females) with a similar age distribution to the mothers sample and affected girls sample, respectively. We observed no significant excess of skewed XCI in families with ASD. Interestingly, two mothers and one girl carrying known mutations in X-linked genes (NLGN3, ATRX, MECP2) showed highly skewed XCI, suggesting that ascertainment of XCI could reveal families with X-linked mutations. Linkage analysis was carried out in the subgroup of multiplex families with skewed XCI (80:20) and a modest increased allele sharing was obtained in the Xq27-Xq28 region, with a peak Z-score of 1.75 close to rs719489. In summary, our results suggest that there is no major X-linked gene subject to XCI and expressed in blood cells conferring susceptibility to ASD. However, the possibility that rare mutations in X-linked genes could contribute to ASD cannot be excluded. We propose that the XCI profile could be a useful criteria to prioritize families for mutation screening of X-linked candidate genes.}}, author = {{Gong, Ziaohong and Bacchelli, Elena and Blasi, Francesca and Toma, Claudio and Betancur, Catalina and Chaste, Pauline and Delorme, Richard and Durand, Christelle M and Fauchereau, Fabien and Goubran Botros, Hany and Leboyer, Marion and Mouren-Simeoni, Marie-Christine and Nygren, Gudrun and Anckarsäter, Henrik and Råstam, Maria and Gillberg, Carina and Gillberg, Christopher and Moreno-De-Luca, Daniel and Carone, Simona and Nummela, Ilona and Rossi, Mari and Battaglia, Agatino and Jarvela, Irma and Maestrini, Elena and Bourgeron, Thomas}}, issn = {{1552-4841}}, keywords = {{autistic disorder skewed X-inactivation; linkage study; X-linked mutation}}, language = {{eng}}, number = {{6}}, pages = {{830--835}}, publisher = {{International Society of Psychiatric Genetics}}, series = {{American Journal of Medical Genetics Part B: Neuropsychiatric Genetics}}, title = {{Analysis of X chromosome inactivation in autism spectrum disorders}}, url = {{http://dx.doi.org/10.1002/ajmg.b.30688}}, doi = {{10.1002/ajmg.b.30688}}, volume = {{147B}}, year = {{2008}}, }