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Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.

Weber, Daniela ; Erosa, Gilda LU ; Sterner, Olov LU and Anke, Timm (2006) In Journal of Antibiotics 59(8). p.495-499
Abstract
In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cylindrocarpon, cytotoxic, new metabolite, cyclopeptide
in
Journal of Antibiotics
volume
59
issue
8
pages
495 - 499
publisher
Japan Antibiotics Research Association
external identifiers
  • wos:000240519800008
  • scopus:33749497718
ISSN
0021-8820
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
f56a1635-2b30-4c93-bc18-4caacd14db75 (old id 393071)
alternative location
http://www.jstage.jst.go.jp/article/antibiotics/59/8/59_495/_article
date added to LUP
2016-04-01 15:56:10
date last changed
2021-04-27 02:32:22
@article{f56a1635-2b30-4c93-bc18-4caacd14db75,
  abstract     = {In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.},
  author       = {Weber, Daniela and Erosa, Gilda and Sterner, Olov and Anke, Timm},
  issn         = {0021-8820},
  language     = {eng},
  number       = {8},
  pages        = {495--499},
  publisher    = {Japan Antibiotics Research Association},
  series       = {Journal of Antibiotics},
  title        = {Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.},
  url          = {http://www.jstage.jst.go.jp/article/antibiotics/59/8/59_495/_article},
  volume       = {59},
  year         = {2006},
}