Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.
(2006) In Journal of Antibiotics 59(8). p.495-499- Abstract
- In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/393071
- author
- Weber, Daniela ; Erosa, Gilda LU ; Sterner, Olov LU and Anke, Timm
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cylindrocarpon, cytotoxic, new metabolite, cyclopeptide
- in
- Journal of Antibiotics
- volume
- 59
- issue
- 8
- pages
- 495 - 499
- publisher
- Japan Antibiotics Research Association
- external identifiers
-
- wos:000240519800008
- scopus:33749497718
- ISSN
- 0021-8820
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- f56a1635-2b30-4c93-bc18-4caacd14db75 (old id 393071)
- alternative location
- http://www.jstage.jst.go.jp/article/antibiotics/59/8/59_495/_article
- date added to LUP
- 2016-04-01 15:56:10
- date last changed
- 2022-01-28 08:06:07
@article{f56a1635-2b30-4c93-bc18-4caacd14db75,
abstract = {{In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.}},
author = {{Weber, Daniela and Erosa, Gilda and Sterner, Olov and Anke, Timm}},
issn = {{0021-8820}},
keywords = {{cylindrocarpon; cytotoxic; new metabolite; cyclopeptide}},
language = {{eng}},
number = {{8}},
pages = {{495--499}},
publisher = {{Japan Antibiotics Research Association}},
series = {{Journal of Antibiotics}},
title = {{Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.}},
url = {{http://www.jstage.jst.go.jp/article/antibiotics/59/8/59_495/_article}},
volume = {{59}},
year = {{2006}},
}