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International Standard reagents for harmonization of HPV serology and DNA assays - an update

Pagliusi, Sonia R. ; Dillner, Joakim LU ; Pawlita, Michael ; Quint, Wim G. V. ; Wheeler, Cosette M. and Ferguson, M. (2006) In Vaccine 24(Suppl. 3). p.193-200
Abstract
International reference materials such as International Standard reagents facilitate quality assurance of essential biopharmaceutical products and related in vitro diagnostic tests. Standardization of antibody and DNA measurements and harmonization of laboratory procedures are key to the success of cancer prevention strategies through screening methods as well as for development and implementation of vaccination against the human papillomavirus (HPV). The WHO supported the preparation and initial analysis of a panel of candidate serological and DNA reference reagents aimed at facilitating inter-laboratory comparisons and detection of HPV worldwide. Two international collaborative studies assessed the performance of various HPV antibody and... (More)
International reference materials such as International Standard reagents facilitate quality assurance of essential biopharmaceutical products and related in vitro diagnostic tests. Standardization of antibody and DNA measurements and harmonization of laboratory procedures are key to the success of cancer prevention strategies through screening methods as well as for development and implementation of vaccination against the human papillomavirus (HPV). The WHO supported the preparation and initial analysis of a panel of candidate serological and DNA reference reagents aimed at facilitating inter-laboratory comparisons and detection of HPV worldwide. Two international collaborative studies assessed the performance of various HPV antibody and HPV-DNA detection assays and examined the feasibility of generating HPV antibody and DNA standard reagents. These studies showed that improvement in performance and comparability of assays is urgently needed and that the use of the same International Standard reference reagent could significantly improve performance and comparability. It is hoped that the establishment of International Units and International Standards for HPV antibody and DNA analysis will be pursued with high priority. (c) 2006 Elsevier Ltd. All rights reserved. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
assays, DNA evaluation, HPV, serological
in
Vaccine
volume
24
issue
Suppl. 3
pages
193 - 200
publisher
Elsevier
external identifiers
  • wos:000240470000025
  • scopus:33747878219
ISSN
1873-2518
DOI
10.1016/j.vaccine.2006.06.016
language
English
LU publication?
yes
id
f5dc2faa-baf0-45e5-b6c7-642a4004bcc7 (old id 393336)
date added to LUP
2016-04-01 11:34:14
date last changed
2021-08-04 03:46:13
@article{f5dc2faa-baf0-45e5-b6c7-642a4004bcc7,
  abstract     = {International reference materials such as International Standard reagents facilitate quality assurance of essential biopharmaceutical products and related in vitro diagnostic tests. Standardization of antibody and DNA measurements and harmonization of laboratory procedures are key to the success of cancer prevention strategies through screening methods as well as for development and implementation of vaccination against the human papillomavirus (HPV). The WHO supported the preparation and initial analysis of a panel of candidate serological and DNA reference reagents aimed at facilitating inter-laboratory comparisons and detection of HPV worldwide. Two international collaborative studies assessed the performance of various HPV antibody and HPV-DNA detection assays and examined the feasibility of generating HPV antibody and DNA standard reagents. These studies showed that improvement in performance and comparability of assays is urgently needed and that the use of the same International Standard reference reagent could significantly improve performance and comparability. It is hoped that the establishment of International Units and International Standards for HPV antibody and DNA analysis will be pursued with high priority. (c) 2006 Elsevier Ltd. All rights reserved.},
  author       = {Pagliusi, Sonia R. and Dillner, Joakim and Pawlita, Michael and Quint, Wim G. V. and Wheeler, Cosette M. and Ferguson, M.},
  issn         = {1873-2518},
  language     = {eng},
  number       = {Suppl. 3},
  pages        = {193--200},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {International Standard reagents for harmonization of HPV serology and DNA assays - an update},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2006.06.016},
  doi          = {10.1016/j.vaccine.2006.06.016},
  volume       = {24},
  year         = {2006},
}