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Aquaporin gating

Hedfalk, Kristina ; Tornroth-Horsefield, Susanna LU ; Nyblom, Maria ; Johanson, Urban LU orcid ; Kjellbom, Per LU and Neutze, Richard (2006) In Current Opinion in Structural Biology 16(4). p.447-456
Abstract
An acceleration in the rate at which new aquaporin structures are determined means that structural models are now available for mammalian AQP0, AQP1, AQP2 and AQP4, bacterial GlpF, AqpM and AQPZ, and the plant SoPIP2;1. With an apparent consensus emerging concerning the mechanism of selective water transport and proton extrusion, emphasis has shifted towards the issues of substrate selectivity and the mechanisms of aquaporin regulation. In particular, recently determined structures of plant SoPIP2;1, sheep and bovine AQP0, and Escherichia coli AQPZ provide new insights into the underlying structural mechanisms by which water transport rates are regulated in diverse organisms. From these results, two distinct pictures of 'capping' and... (More)
An acceleration in the rate at which new aquaporin structures are determined means that structural models are now available for mammalian AQP0, AQP1, AQP2 and AQP4, bacterial GlpF, AqpM and AQPZ, and the plant SoPIP2;1. With an apparent consensus emerging concerning the mechanism of selective water transport and proton extrusion, emphasis has shifted towards the issues of substrate selectivity and the mechanisms of aquaporin regulation. In particular, recently determined structures of plant SoPIP2;1, sheep and bovine AQP0, and Escherichia coli AQPZ provide new insights into the underlying structural mechanisms by which water transport rates are regulated in diverse organisms. From these results, two distinct pictures of 'capping' and 'pinching' have emerged to describe aquaporin gating. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Structural Biology
volume
16
issue
4
pages
447 - 456
publisher
Elsevier
external identifiers
  • wos:000240157000004
  • scopus:33746596999
ISSN
1879-033X
DOI
10.1016/j.sbi.2006.06.009
language
English
LU publication?
yes
id
d686f20c-4ed9-4748-ba77-7520219db4ec (old id 394791)
date added to LUP
2016-04-01 12:28:57
date last changed
2020-11-10 02:08:05
@article{d686f20c-4ed9-4748-ba77-7520219db4ec,
  abstract     = {An acceleration in the rate at which new aquaporin structures are determined means that structural models are now available for mammalian AQP0, AQP1, AQP2 and AQP4, bacterial GlpF, AqpM and AQPZ, and the plant SoPIP2;1. With an apparent consensus emerging concerning the mechanism of selective water transport and proton extrusion, emphasis has shifted towards the issues of substrate selectivity and the mechanisms of aquaporin regulation. In particular, recently determined structures of plant SoPIP2;1, sheep and bovine AQP0, and Escherichia coli AQPZ provide new insights into the underlying structural mechanisms by which water transport rates are regulated in diverse organisms. From these results, two distinct pictures of 'capping' and 'pinching' have emerged to describe aquaporin gating.},
  author       = {Hedfalk, Kristina and Tornroth-Horsefield, Susanna and Nyblom, Maria and Johanson, Urban and Kjellbom, Per and Neutze, Richard},
  issn         = {1879-033X},
  language     = {eng},
  number       = {4},
  pages        = {447--456},
  publisher    = {Elsevier},
  series       = {Current Opinion in Structural Biology},
  title        = {Aquaporin gating},
  url          = {http://dx.doi.org/10.1016/j.sbi.2006.06.009},
  doi          = {10.1016/j.sbi.2006.06.009},
  volume       = {16},
  year         = {2006},
}