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Three predominant prostatic proteins : Drei vorherrschende Prostataproteine

Abrahamsson, P. ‐A LU and Lilja, H. LU orcid (1990) In Andrologia 22(1 S). p.122-131
Abstract

Summary Prostatic acid phosphatase (PAP), prostate‐specific antigen (PSA; or γ‐seminoprotein), and β‐microseminoprotein (β‐MSP; PSP94 or β‐inhibin) are the three predominant proteins secreted by the normal human prostate gland. In the epithelium of normal and hyperplastic prostatic acini and ducts PAP, PSA and β‐MSP have an identical immunohistochemical localization. Highly differentiated (grade I) carcinomas contain an almost equal number of PAP‐, PSA‐ and β‐MSP‐immunoreactive cells; the incidence of these cells is lower and they display a greater staining variability in the moderately and poorly (grade II‐III) differentiated tumours. Especially in poorly differentiated tumours PSA seems to be a more sensitive... (More)

Summary Prostatic acid phosphatase (PAP), prostate‐specific antigen (PSA; or γ‐seminoprotein), and β‐microseminoprotein (β‐MSP; PSP94 or β‐inhibin) are the three predominant proteins secreted by the normal human prostate gland. In the epithelium of normal and hyperplastic prostatic acini and ducts PAP, PSA and β‐MSP have an identical immunohistochemical localization. Highly differentiated (grade I) carcinomas contain an almost equal number of PAP‐, PSA‐ and β‐MSP‐immunoreactive cells; the incidence of these cells is lower and they display a greater staining variability in the moderately and poorly (grade II‐III) differentiated tumours. Especially in poorly differentiated tumours PSA seems to be a more sensitive immunohistochemical marker than PAP or prostatic carcinomas. Moreover, the use of PAP as a marker for prostatic carcinomas is complicated by the reported structural similarities between the prostatic secreted acid phosphatase and lysosomal acid phosphatase occurring in all tissues. The use of β‐MSP as a marker for prostatic carcinomas may be limited by indications of non‐prostatic production of this protein.

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Contribution to journal
publication status
published
subject
keywords
kallikreins, prostate‐specific antigen, Prostatic acid phosphatase, PSP, serine proteases, β‐inhibin, β‐microseminoprotein, γ‐seminoprotein
in
Andrologia
volume
22
issue
1 S
pages
122 - 131
publisher
Wiley-Blackwell
external identifiers
  • pmid:1720287
  • scopus:0025542624
ISSN
0303-4569
DOI
10.1111/j.1439-0272.1990.tb02078.x
language
English
LU publication?
yes
additional info
Abstract in German Zusammenfassung Saure Prostata‐Phosphatase (PAP), Prostata‐spezifisches Antigen (PSA; oder γ‐Seminoprotein) und β‐Mikroseminoprotein (β‐MSP; PSP94 oder β‐Inhibin) sind die drei vorherrschenden Proteine, die von der normalen Prostata sezerniert werden. Im Epithel normaler und hyperplastischer Prostata‐Azini und Drüsengänge haben PAP, PSA und β‐MSP eine identische immunhistochemische Lokalisation. Hoch differenzierte (Grad I) Karzinome enthalten annähernd gleiche Anzahlen von PAP‐, PSA‐ und β‐MSP‐immunreaktiven Zellen; das Auftreten dieser Zellen in mäßig und wenig differenzierten (Grad II, III) Tumoren ist geringer und sie zeigen eine erhöhte Variabilität in der Anfärbung. Vor allem in wenig differenzierten Prostatakarzinomen scheint PSA ein sensitiverer immunhistochemischer Marker als PAP zu sein. Uberdies ist die Anwendung von PAP als Marker für Prostatakarzinome durch die beschriebene strukturelle Ähnlichkeit zwischen der sekretorischen Prostataphosphatase und der lysosomalen sauren Phosphatase aus alien übrigen Geweben kompliziert. Die Anwendung von β‐MSP als Marker für Prostatakarzinome könnte durch die extraprostatische Produktion dieses Proteins belastet sein. 1990 Blackwell Verlag GmbH
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394d6fd6-07ab-40ca-b41d-e5fbede918ee
date added to LUP
2022-12-08 13:09:10
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2024-01-02 13:55:50
@article{394d6fd6-07ab-40ca-b41d-e5fbede918ee,
  abstract     = {{<p>Summary Prostatic acid phosphatase (PAP), prostate‐specific antigen (PSA; or γ‐seminoprotein), and β‐microseminoprotein (β‐MSP; PSP<sub>94</sub> or β‐inhibin) are the three predominant proteins secreted by the normal human prostate gland. In the epithelium of normal and hyperplastic prostatic acini and ducts PAP, PSA and β‐MSP have an identical immunohistochemical localization. Highly differentiated (grade I) carcinomas contain an almost equal number of PAP‐, PSA‐ and β‐MSP‐immunoreactive cells; the incidence of these cells is lower and they display a greater staining variability in the moderately and poorly (grade II‐III) differentiated tumours. Especially in poorly differentiated tumours PSA seems to be a more sensitive immunohistochemical marker than PAP or prostatic carcinomas. Moreover, the use of PAP as a marker for prostatic carcinomas is complicated by the reported structural similarities between the prostatic secreted acid phosphatase and lysosomal acid phosphatase occurring in all tissues. The use of β‐MSP as a marker for prostatic carcinomas may be limited by indications of non‐prostatic production of this protein.</p>}},
  author       = {{Abrahamsson, P. ‐A and Lilja, H.}},
  issn         = {{0303-4569}},
  keywords     = {{kallikreins; prostate‐specific antigen; Prostatic acid phosphatase; PSP; serine proteases; β‐inhibin; β‐microseminoprotein; γ‐seminoprotein}},
  language     = {{eng}},
  number       = {{1 S}},
  pages        = {{122--131}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Andrologia}},
  title        = {{Three predominant prostatic proteins : Drei vorherrschende Prostataproteine}},
  url          = {{http://dx.doi.org/10.1111/j.1439-0272.1990.tb02078.x}},
  doi          = {{10.1111/j.1439-0272.1990.tb02078.x}},
  volume       = {{22}},
  year         = {{1990}},
}