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Fetal and perinatal risk factors for inflammatory bowel disease

Aspberg, Sara ; Dahlquist, Gisela ; Kahan, Thomas and Källén, Bengt LU (2006) In Acta Pædiatrica 95(8). p.1001-1004
Abstract
Aim: To study the influence of specific factors and events during pregnancy and the perinatal period on the risk of children developing inflammatory bowel disease. Methods: Population-based national register study. Linkage between the Swedish Medical Birth Register and the Swedish Hospital Discharge Register during the period 1987 to 2000 identified 455 singleton infants who later developed inflammatory bowel disease. Data for these children were compared with data for all children born in Sweden during the same period. Results: Smoking during early pregnancy reduced the risk of inflammatory bowel disease ( odds ratio ( OR) 0.71, 95% CI 0.55-0.91). For ulcerative colitis the odds ratio was 0.70 ( 95% CI 0.56-0.86), and for Crohn's disease... (More)
Aim: To study the influence of specific factors and events during pregnancy and the perinatal period on the risk of children developing inflammatory bowel disease. Methods: Population-based national register study. Linkage between the Swedish Medical Birth Register and the Swedish Hospital Discharge Register during the period 1987 to 2000 identified 455 singleton infants who later developed inflammatory bowel disease. Data for these children were compared with data for all children born in Sweden during the same period. Results: Smoking during early pregnancy reduced the risk of inflammatory bowel disease ( odds ratio ( OR) 0.71, 95% CI 0.55-0.91). For ulcerative colitis the odds ratio was 0.70 ( 95% CI 0.56-0.86), and for Crohn's disease 0.73 ( 95% CI 0.58 - 0.94). Infections during the neonatal period seemed to increase the risk of inflammatory bowel disease ( OR 17.6, 95% CI 3.6 - 51.6), but the number of observed events was small. The other factors examined did not influence the risk of inflammatory bowel disease. Conclusion: Maternal smoking during early pregnancy reduces the risk for the child to be hospitalized with a diagnosis of inflammatory bowel disease. Severe neonatal infections may increase the risk. Thus, some exposures during the fetal and neonatal period seem to affect the risk of inflammatory bowel disease later in life. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ulcerative colitis, smoking, Crohn's disease, neonatal infection
in
Acta Pædiatrica
volume
95
issue
8
pages
1001 - 1004
publisher
Wiley-Blackwell
external identifiers
  • wos:000239953000020
  • scopus:33746822630
  • pmid:16882577
ISSN
1651-2227
DOI
10.1080/08035250600573151
language
English
LU publication?
yes
id
bf7ef3ce-1099-4104-a3ab-051a02903c60 (old id 395380)
date added to LUP
2016-04-01 16:48:50
date last changed
2021-06-08 04:19:07
@article{bf7ef3ce-1099-4104-a3ab-051a02903c60,
  abstract     = {Aim: To study the influence of specific factors and events during pregnancy and the perinatal period on the risk of children developing inflammatory bowel disease. Methods: Population-based national register study. Linkage between the Swedish Medical Birth Register and the Swedish Hospital Discharge Register during the period 1987 to 2000 identified 455 singleton infants who later developed inflammatory bowel disease. Data for these children were compared with data for all children born in Sweden during the same period. Results: Smoking during early pregnancy reduced the risk of inflammatory bowel disease ( odds ratio ( OR) 0.71, 95% CI 0.55-0.91). For ulcerative colitis the odds ratio was 0.70 ( 95% CI 0.56-0.86), and for Crohn's disease 0.73 ( 95% CI 0.58 - 0.94). Infections during the neonatal period seemed to increase the risk of inflammatory bowel disease ( OR 17.6, 95% CI 3.6 - 51.6), but the number of observed events was small. The other factors examined did not influence the risk of inflammatory bowel disease. Conclusion: Maternal smoking during early pregnancy reduces the risk for the child to be hospitalized with a diagnosis of inflammatory bowel disease. Severe neonatal infections may increase the risk. Thus, some exposures during the fetal and neonatal period seem to affect the risk of inflammatory bowel disease later in life.},
  author       = {Aspberg, Sara and Dahlquist, Gisela and Kahan, Thomas and Källén, Bengt},
  issn         = {1651-2227},
  language     = {eng},
  number       = {8},
  pages        = {1001--1004},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Pædiatrica},
  title        = {Fetal and perinatal risk factors for inflammatory bowel disease},
  url          = {http://dx.doi.org/10.1080/08035250600573151},
  doi          = {10.1080/08035250600573151},
  volume       = {95},
  year         = {2006},
}