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Portal vein thrombosis: Prevalence, patient, characteristics and lifetime risk: A population study based on 23796 consecutive autopsies

Ogren, Mats ; Bergqvist, David ; Bjorck, Martin ; Acosta, Stefan LU orcid ; Eriksson, Henry and Sternby, Nils (2006) In World Journal of Gastroenterology 12(13). p.2115-2119
Abstract
AIM: To assess the lifetime cumulative incidence of portal venous thrombosis (PVT) in the general population. METHODS: Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS: The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had... (More)
AIM: To assess the lifetime cumulative incidence of portal venous thrombosis (PVT) in the general population. METHODS: Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS: The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had a myeloproliferative disorder. Patients with both cirrhosis and hepatic carcinoma had the highest PVT risk, OR 17.1 (95% CI 11.1-26.4). In 14% no cause was found; only a minority of them had developed portal-hypertension-related complications. CONCLUSION: In this population-based study, PVT was found to be more common than indicated by previous clinical series. The markedly excess risk in cirrhosis and hepatic carcinoma should warrant an increased awareness in these patients for whom prospective studies of directed intervention might be considered. (C) 2006 The WJG Press. All rights reserved. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
portal hypertension, epidemiology, venous thrombosis, gastrointestinal cancer, cirrhosis
in
World Journal of Gastroenterology
volume
12
issue
13
pages
2115 - 2119
publisher
WJG Press
external identifiers
  • wos:000239996100023
  • pmid:16610067
  • scopus:33646441796
ISSN
1007-9327
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Pathology (Malmö) (013031000)
id
769ee6fa-5833-4baf-a506-9dc22580ae4f (old id 395405)
alternative location
http://www.wjgnet.com/1007-9327/12/2115.asp
date added to LUP
2016-04-01 12:07:21
date last changed
2021-09-22 04:43:33
@article{769ee6fa-5833-4baf-a506-9dc22580ae4f,
  abstract     = {AIM: To assess the lifetime cumulative incidence of portal venous thrombosis (PVT) in the general population. METHODS: Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS: The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had a myeloproliferative disorder. Patients with both cirrhosis and hepatic carcinoma had the highest PVT risk, OR 17.1 (95% CI 11.1-26.4). In 14% no cause was found; only a minority of them had developed portal-hypertension-related complications. CONCLUSION: In this population-based study, PVT was found to be more common than indicated by previous clinical series. The markedly excess risk in cirrhosis and hepatic carcinoma should warrant an increased awareness in these patients for whom prospective studies of directed intervention might be considered. (C) 2006 The WJG Press. All rights reserved.},
  author       = {Ogren, Mats and Bergqvist, David and Bjorck, Martin and Acosta, Stefan and Eriksson, Henry and Sternby, Nils},
  issn         = {1007-9327},
  language     = {eng},
  number       = {13},
  pages        = {2115--2119},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Portal vein thrombosis: Prevalence, patient, characteristics and lifetime risk: A population study based on 23796 consecutive autopsies},
  url          = {http://www.wjgnet.com/1007-9327/12/2115.asp},
  volume       = {12},
  year         = {2006},
}