Portal vein thrombosis: Prevalence, patient, characteristics and lifetime risk: A population study based on 23796 consecutive autopsies
Ogren, Mats ; Bergqvist, David ; Bjorck, Martin ; Acosta, Stefan LU
; Eriksson, Henry
and Sternby, Nils
LU
(2006)
In World Journal of Gastroenterology
12(13).
p.2115-2119
- Abstract
- AIM: To assess the lifetime cumulative incidence of portal venous thrombosis (PVT) in the general population. METHODS: Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS: The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had... (More)
- AIM: To assess the lifetime cumulative incidence of portal venous thrombosis (PVT) in the general population. METHODS: Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS: The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had a myeloproliferative disorder. Patients with both cirrhosis and hepatic carcinoma had the highest PVT risk, OR 17.1 (95% CI 11.1-26.4). In 14% no cause was found; only a minority of them had developed portal-hypertension-related complications. CONCLUSION: In this population-based study, PVT was found to be more common than indicated by previous clinical series. The markedly excess risk in cirrhosis and hepatic carcinoma should warrant an increased awareness in these patients for whom prospective studies of directed intervention might be considered. (C) 2006 The WJG Press. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/395405
- author
- Ogren, Mats
; Bergqvist, David
; Bjorck, Martin
; Acosta, Stefan
LU
; Eriksson, Henry
and Sternby, Nils
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- portal hypertension, epidemiology, venous thrombosis, gastrointestinal cancer, cirrhosis
- in
- World Journal of Gastroenterology
- volume
- 12
- issue
- 13
- pages
- 2115 - 2119
- publisher
- WJG Press
- external identifiers
-
- wos:000239996100023
- pmid:16610067
- scopus:33646441796
- ISSN
- 1007-9327
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Pathology (Malmö) (013031000)
- id
- 769ee6fa-5833-4baf-a506-9dc22580ae4f (old id 395405)
- alternative location
- http://www.wjgnet.com/1007-9327/12/2115.asp
- date added to LUP
- 2016-04-01 12:07:21
- date last changed
- 2022-05-06 22:01:43
@article{769ee6fa-5833-4baf-a506-9dc22580ae4f,
abstract = {{AIM: To assess the lifetime cumulative incidence of portal venous thrombosis (PVT) in the general population. METHODS: Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS: The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had a myeloproliferative disorder. Patients with both cirrhosis and hepatic carcinoma had the highest PVT risk, OR 17.1 (95% CI 11.1-26.4). In 14% no cause was found; only a minority of them had developed portal-hypertension-related complications. CONCLUSION: In this population-based study, PVT was found to be more common than indicated by previous clinical series. The markedly excess risk in cirrhosis and hepatic carcinoma should warrant an increased awareness in these patients for whom prospective studies of directed intervention might be considered. (C) 2006 The WJG Press. All rights reserved.}},
author = {{Ogren, Mats and Bergqvist, David and Bjorck, Martin and Acosta, Stefan and Eriksson, Henry and Sternby, Nils}},
issn = {{1007-9327}},
keywords = {{portal hypertension; epidemiology; venous thrombosis; gastrointestinal cancer; cirrhosis}},
language = {{eng}},
number = {{13}},
pages = {{2115--2119}},
publisher = {{WJG Press}},
series = {{World Journal of Gastroenterology}},
title = {{Portal vein thrombosis: Prevalence, patient, characteristics and lifetime risk: A population study based on 23796 consecutive autopsies}},
url = {{http://www.wjgnet.com/1007-9327/12/2115.asp}},
volume = {{12}},
year = {{2006}},
}