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A two-dimensional model for stress driven diffusion in bone tissue.

Lindberg, Gustav LU ; Banks-Sills, Leslie LU ; Ståhle, Per LU and Svensson, Ingrid LU (2015) In Computer Methods in Biomechanics and Biomedical Engineering 18(5). p.457-467
Abstract
The growth and resorption of bone are governed by interaction between several cells such as bone-forming osteoblasts, osteocytes, lining cells and bone-resorbing osteoclasts. The cells considered in this study reside in the periosteum. Furthermore, they are believed to be activated by certain substances to initiate bone growth. This study focuses on the role that stress driven diffusion plays in the transport of these substances from the medullary cavity to the periosteum. Calculations of stress driven diffusion are performed under steady state conditions using a finite element method with the concentration of nutrients in the cambium layer of the periosteum obtained for different choices of load frequencies. The results are compared with... (More)
The growth and resorption of bone are governed by interaction between several cells such as bone-forming osteoblasts, osteocytes, lining cells and bone-resorbing osteoclasts. The cells considered in this study reside in the periosteum. Furthermore, they are believed to be activated by certain substances to initiate bone growth. This study focuses on the role that stress driven diffusion plays in the transport of these substances from the medullary cavity to the periosteum. Calculations of stress driven diffusion are performed under steady state conditions using a finite element method with the concentration of nutrients in the cambium layer of the periosteum obtained for different choices of load frequencies. The results are compared with experimental findings, suggesting that increased bone growth occurs in the neighbourhood of relatively high nutrient concentration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone growth, diffusion, stress enhanced, finite element method, steady-state, periosteal membrane
in
Computer Methods in Biomechanics and Biomedical Engineering
volume
18
issue
5
pages
457 - 467
publisher
Taylor & Francis
external identifiers
  • pmid:23865643
  • wos:000345142700001
  • scopus:84911990109
ISSN
1025-5842
DOI
10.1080/10255842.2013.807507
language
English
LU publication?
yes
id
c3c631ab-628b-40ea-a5bc-f64e1cb10d2e (old id 3955807)
date added to LUP
2013-08-06 12:05:29
date last changed
2017-01-01 03:55:54
@article{c3c631ab-628b-40ea-a5bc-f64e1cb10d2e,
  abstract     = {The growth and resorption of bone are governed by interaction between several cells such as bone-forming osteoblasts, osteocytes, lining cells and bone-resorbing osteoclasts. The cells considered in this study reside in the periosteum. Furthermore, they are believed to be activated by certain substances to initiate bone growth. This study focuses on the role that stress driven diffusion plays in the transport of these substances from the medullary cavity to the periosteum. Calculations of stress driven diffusion are performed under steady state conditions using a finite element method with the concentration of nutrients in the cambium layer of the periosteum obtained for different choices of load frequencies. The results are compared with experimental findings, suggesting that increased bone growth occurs in the neighbourhood of relatively high nutrient concentration.},
  author       = {Lindberg, Gustav and Banks-Sills, Leslie and Ståhle, Per and Svensson, Ingrid},
  issn         = {1025-5842},
  keyword      = {bone growth,diffusion,stress enhanced,finite element method,steady-state,periosteal membrane},
  language     = {eng},
  number       = {5},
  pages        = {457--467},
  publisher    = {Taylor & Francis},
  series       = {Computer Methods in Biomechanics and Biomedical Engineering},
  title        = {A two-dimensional model for stress driven diffusion in bone tissue.},
  url          = {http://dx.doi.org/10.1080/10255842.2013.807507},
  volume       = {18},
  year         = {2015},
}