Intervention thresholds for osteoporosis in men and women: a study based on data from Sweden
(2005) In Osteoporosis International 16(1). p.41439-41439- Abstract
- The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in men and women, based on data from Sweden. We modeled the effects of a treatment costing $500 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect for a further 5 years. Sensitivity analyses included a range of effectiveness (10-50%) and a range of intervention costs ($200-500/year). Data on costs and risks were from Sweden. Costs included direct costs, but excluded indirect costs due to morbidity. A threshold for cost-effectiveness of approximately $45,000/QALY gained was used. Cost of added years was included in a sensitivity analysis. With the base... (More)
- The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in men and women, based on data from Sweden. We modeled the effects of a treatment costing $500 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect for a further 5 years. Sensitivity analyses included a range of effectiveness (10-50%) and a range of intervention costs ($200-500/year). Data on costs and risks were from Sweden. Costs included direct costs, but excluded indirect costs due to morbidity. A threshold for cost-effectiveness of approximately $45,000/QALY gained was used. Cost of added years was included in a sensitivity analysis. With the base case ($500 per year; 35% efficacy) treatment in women was cost-effective with a 10-year hip fracture probability that ranged from 1.2% at the age of 50 years to 7.4% at the age of 80 years. Similar results were observed in men except that the threshold for cost-effectiveness was higher at younger ages than in women (2.0 vs 1.2%, respectively, at the age of 50 years). Intervention thresholds were sensitive to the assumed effectiveness and intervention cost. The exclusion of osteoporotic fractures other than hip fracture significantly increased the cost-effectiveness ratio because of the substantial morbidity from such other fractures, particularly at younger ages. We conclude that the inclusion of all osteoporotic fractures has a marked effect on intervention thresholds, that these vary with age, and that available treatments can be targeted cost-effectively to individuals at moderately increased fracture risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/897675
- author
- Kanis, JA ; Johnell, Olof LU ; Oden, A ; Borgstrom, F ; Johansson, H ; De Laet, C and Jonsson, B
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- threshold, osteoporotic fracture, intervention, hip fracture, cost of added years, cost-effectiveness
- in
- Osteoporosis International
- volume
- 16
- issue
- 1
- pages
- 41439 - 41439
- publisher
- Springer
- external identifiers
-
- wos:000226284900002
- pmid:15103452
- scopus:13244251126
- pmid:15103452
- ISSN
- 1433-2965
- DOI
- 10.1007/s00198-004-1623-4
- language
- English
- LU publication?
- yes
- id
- 397275ec-56c5-4e54-a7bc-723ec4b199d4 (old id 897675)
- date added to LUP
- 2016-04-01 16:38:16
- date last changed
- 2022-02-12 23:28:57
@article{397275ec-56c5-4e54-a7bc-723ec4b199d4,
abstract = {{The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in men and women, based on data from Sweden. We modeled the effects of a treatment costing $500 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect for a further 5 years. Sensitivity analyses included a range of effectiveness (10-50%) and a range of intervention costs ($200-500/year). Data on costs and risks were from Sweden. Costs included direct costs, but excluded indirect costs due to morbidity. A threshold for cost-effectiveness of approximately $45,000/QALY gained was used. Cost of added years was included in a sensitivity analysis. With the base case ($500 per year; 35% efficacy) treatment in women was cost-effective with a 10-year hip fracture probability that ranged from 1.2% at the age of 50 years to 7.4% at the age of 80 years. Similar results were observed in men except that the threshold for cost-effectiveness was higher at younger ages than in women (2.0 vs 1.2%, respectively, at the age of 50 years). Intervention thresholds were sensitive to the assumed effectiveness and intervention cost. The exclusion of osteoporotic fractures other than hip fracture significantly increased the cost-effectiveness ratio because of the substantial morbidity from such other fractures, particularly at younger ages. We conclude that the inclusion of all osteoporotic fractures has a marked effect on intervention thresholds, that these vary with age, and that available treatments can be targeted cost-effectively to individuals at moderately increased fracture risk.}},
author = {{Kanis, JA and Johnell, Olof and Oden, A and Borgstrom, F and Johansson, H and De Laet, C and Jonsson, B}},
issn = {{1433-2965}},
keywords = {{threshold; osteoporotic fracture; intervention; hip fracture; cost of added years; cost-effectiveness}},
language = {{eng}},
number = {{1}},
pages = {{41439--41439}},
publisher = {{Springer}},
series = {{Osteoporosis International}},
title = {{Intervention thresholds for osteoporosis in men and women: a study based on data from Sweden}},
url = {{http://dx.doi.org/10.1007/s00198-004-1623-4}},
doi = {{10.1007/s00198-004-1623-4}},
volume = {{16}},
year = {{2005}},
}