A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders
(2006) In Kidney International 70(3). p.423-431- Abstract
- The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the causes of the syndrome now permit many patients to be classified according to etiology. The increased precision of a diagnosis based on causation is important for considering logical approaches to treatment and prognosis. It is also essential for research. We propose a classification that accommodates both a current understanding of causation (level 1) and clinical association in cases for whom cause of disease is unclear (level 2). We tested the classification in a pediatric disease registry of HUS. The revised classification is a stimulus to... (More)
- The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the causes of the syndrome now permit many patients to be classified according to etiology. The increased precision of a diagnosis based on causation is important for considering logical approaches to treatment and prognosis. It is also essential for research. We propose a classification that accommodates both a current understanding of causation (level 1) and clinical association in cases for whom cause of disease is unclear (level 2). We tested the classification in a pediatric disease registry of HUS. The revised classification is a stimulus to comprehensive investigation of all cases of HUS and TTP and is expected to increase the proportion of cases in whom a level 1 etiological diagnosis is confirmed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/399059
- author
- Besbas, N. ; Karpman, Diana LU ; Landau, D. ; Loirat, C. ; Proesmans, W. ; Remuzzi, G. ; Rizzoni, G. ; Taylor, C. M. ; Van de Kar, N. and Zimmerhackl, L. B.
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, etiology
- in
- Kidney International
- volume
- 70
- issue
- 3
- pages
- 423 - 431
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000239390200006
- scopus:33746508999
- ISSN
- 1523-1755
- DOI
- 10.1038/sj.ki.5001581
- language
- English
- LU publication?
- yes
- id
- d45379bd-2484-4b5b-b50b-edf949bcba25 (old id 399059)
- date added to LUP
- 2016-04-01 16:34:54
- date last changed
- 2022-04-22 23:01:52
@article{d45379bd-2484-4b5b-b50b-edf949bcba25, abstract = {{The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the causes of the syndrome now permit many patients to be classified according to etiology. The increased precision of a diagnosis based on causation is important for considering logical approaches to treatment and prognosis. It is also essential for research. We propose a classification that accommodates both a current understanding of causation (level 1) and clinical association in cases for whom cause of disease is unclear (level 2). We tested the classification in a pediatric disease registry of HUS. The revised classification is a stimulus to comprehensive investigation of all cases of HUS and TTP and is expected to increase the proportion of cases in whom a level 1 etiological diagnosis is confirmed.}}, author = {{Besbas, N. and Karpman, Diana and Landau, D. and Loirat, C. and Proesmans, W. and Remuzzi, G. and Rizzoni, G. and Taylor, C. M. and Van de Kar, N. and Zimmerhackl, L. B.}}, issn = {{1523-1755}}, keywords = {{hemolytic uremic syndrome; thrombotic thrombocytopenic purpura; etiology}}, language = {{eng}}, number = {{3}}, pages = {{423--431}}, publisher = {{Nature Publishing Group}}, series = {{Kidney International}}, title = {{A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders}}, url = {{http://dx.doi.org/10.1038/sj.ki.5001581}}, doi = {{10.1038/sj.ki.5001581}}, volume = {{70}}, year = {{2006}}, }