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A model for the drug release from a polymer matrix tablet - effects of swelling and dissolution

Borgquist, Per LU ; Körner, Anna LU ; Piculell, Lennart LU ; Larsson, Anette and Axelsson, Anders LU (2006) In Journal of Controlled Release 113(3). p.216-225
Abstract
A model for simulating the drug release from a swelling and dissolving polymer tablet is presented and verified to data. The model is based on a mechanistic approach, and it can therefore be employed to study the sensitivity of true physical constants, for instance the drug diffusion coefficient or the drug solubility. The model generates the drug and polymer release profiles and the front positions of the total tablet, the solid core, and of the solid-drug-solubilized-drug interface. The convective contribution to mass transfer is shown to be of great importance. This is most markedly noticed for slowly diffusing drugs. In a simulation with a low value of the drug diffusion coefficient, it is shown that the initial drug release rate is... (More)
A model for simulating the drug release from a swelling and dissolving polymer tablet is presented and verified to data. The model is based on a mechanistic approach, and it can therefore be employed to study the sensitivity of true physical constants, for instance the drug diffusion coefficient or the drug solubility. The model generates the drug and polymer release profiles and the front positions of the total tablet, the solid core, and of the solid-drug-solubilized-drug interface. The convective contribution to mass transfer is shown to be of great importance. This is most markedly noticed for slowly diffusing drugs. In a simulation with a low value of the drug diffusion coefficient, it is shown that the initial drug release rate is faster than the polymer dissolution rate, followed by a second stage with a slower drug release rate. Furthermore, it is shown that polymer dissolution influences the drug release profile significantly, but not the front position of saturated drug in the gel layer. The model is verified against drug release and polymer dissolution data for the slightly soluble drug Methyl paraben and the soluble drug Saligenin in a poly (ethylene oxide) tablet, resulting in good agreement between model and experiments. (c) 2006 Elsevier B.V. All rights reserved. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
polymer dissolution, mathematical model, controlled release, matrix, swelling
in
Journal of Controlled Release
volume
113
issue
3
pages
216 - 225
publisher
Elsevier
external identifiers
  • wos:000239482600003
  • scopus:33745508756
ISSN
1873-4995
DOI
10.1016/j.jconrel.2006.05.004
language
English
LU publication?
yes
id
541ea45f-f9d9-487b-8838-f25e66e50fc6 (old id 399104)
date added to LUP
2016-04-01 11:36:16
date last changed
2021-10-06 05:43:06
@article{541ea45f-f9d9-487b-8838-f25e66e50fc6,
  abstract     = {A model for simulating the drug release from a swelling and dissolving polymer tablet is presented and verified to data. The model is based on a mechanistic approach, and it can therefore be employed to study the sensitivity of true physical constants, for instance the drug diffusion coefficient or the drug solubility. The model generates the drug and polymer release profiles and the front positions of the total tablet, the solid core, and of the solid-drug-solubilized-drug interface. The convective contribution to mass transfer is shown to be of great importance. This is most markedly noticed for slowly diffusing drugs. In a simulation with a low value of the drug diffusion coefficient, it is shown that the initial drug release rate is faster than the polymer dissolution rate, followed by a second stage with a slower drug release rate. Furthermore, it is shown that polymer dissolution influences the drug release profile significantly, but not the front position of saturated drug in the gel layer. The model is verified against drug release and polymer dissolution data for the slightly soluble drug Methyl paraben and the soluble drug Saligenin in a poly (ethylene oxide) tablet, resulting in good agreement between model and experiments. (c) 2006 Elsevier B.V. All rights reserved.},
  author       = {Borgquist, Per and Körner, Anna and Piculell, Lennart and Larsson, Anette and Axelsson, Anders},
  issn         = {1873-4995},
  language     = {eng},
  number       = {3},
  pages        = {216--225},
  publisher    = {Elsevier},
  series       = {Journal of Controlled Release},
  title        = {A model for the drug release from a polymer matrix tablet - effects of swelling and dissolution},
  url          = {http://dx.doi.org/10.1016/j.jconrel.2006.05.004},
  doi          = {10.1016/j.jconrel.2006.05.004},
  volume       = {113},
  year         = {2006},
}