A model for the drug release from a polymer matrix tablet - effects of swelling and dissolution
(2006) In Journal of Controlled Release 113(3). p.216-225- Abstract
- A model for simulating the drug release from a swelling and dissolving polymer tablet is presented and verified to data. The model is based on a mechanistic approach, and it can therefore be employed to study the sensitivity of true physical constants, for instance the drug diffusion coefficient or the drug solubility. The model generates the drug and polymer release profiles and the front positions of the total tablet, the solid core, and of the solid-drug-solubilized-drug interface. The convective contribution to mass transfer is shown to be of great importance. This is most markedly noticed for slowly diffusing drugs. In a simulation with a low value of the drug diffusion coefficient, it is shown that the initial drug release rate is... (More)
- A model for simulating the drug release from a swelling and dissolving polymer tablet is presented and verified to data. The model is based on a mechanistic approach, and it can therefore be employed to study the sensitivity of true physical constants, for instance the drug diffusion coefficient or the drug solubility. The model generates the drug and polymer release profiles and the front positions of the total tablet, the solid core, and of the solid-drug-solubilized-drug interface. The convective contribution to mass transfer is shown to be of great importance. This is most markedly noticed for slowly diffusing drugs. In a simulation with a low value of the drug diffusion coefficient, it is shown that the initial drug release rate is faster than the polymer dissolution rate, followed by a second stage with a slower drug release rate. Furthermore, it is shown that polymer dissolution influences the drug release profile significantly, but not the front position of saturated drug in the gel layer. The model is verified against drug release and polymer dissolution data for the slightly soluble drug Methyl paraben and the soluble drug Saligenin in a poly (ethylene oxide) tablet, resulting in good agreement between model and experiments. (c) 2006 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/399104
- author
- Borgquist, Per LU ; Körner, Anna LU ; Piculell, Lennart LU ; Larsson, Anette and Axelsson, Anders LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- polymer dissolution, mathematical model, controlled release, matrix, swelling
- in
- Journal of Controlled Release
- volume
- 113
- issue
- 3
- pages
- 216 - 225
- publisher
- Elsevier
- external identifiers
-
- wos:000239482600003
- scopus:33745508756
- ISSN
- 1873-4995
- DOI
- 10.1016/j.jconrel.2006.05.004
- language
- English
- LU publication?
- yes
- id
- 541ea45f-f9d9-487b-8838-f25e66e50fc6 (old id 399104)
- date added to LUP
- 2016-04-01 11:36:16
- date last changed
- 2023-12-09 15:38:47
@article{541ea45f-f9d9-487b-8838-f25e66e50fc6,
abstract = {{A model for simulating the drug release from a swelling and dissolving polymer tablet is presented and verified to data. The model is based on a mechanistic approach, and it can therefore be employed to study the sensitivity of true physical constants, for instance the drug diffusion coefficient or the drug solubility. The model generates the drug and polymer release profiles and the front positions of the total tablet, the solid core, and of the solid-drug-solubilized-drug interface. The convective contribution to mass transfer is shown to be of great importance. This is most markedly noticed for slowly diffusing drugs. In a simulation with a low value of the drug diffusion coefficient, it is shown that the initial drug release rate is faster than the polymer dissolution rate, followed by a second stage with a slower drug release rate. Furthermore, it is shown that polymer dissolution influences the drug release profile significantly, but not the front position of saturated drug in the gel layer. The model is verified against drug release and polymer dissolution data for the slightly soluble drug Methyl paraben and the soluble drug Saligenin in a poly (ethylene oxide) tablet, resulting in good agreement between model and experiments. (c) 2006 Elsevier B.V. All rights reserved.}},
author = {{Borgquist, Per and Körner, Anna and Piculell, Lennart and Larsson, Anette and Axelsson, Anders}},
issn = {{1873-4995}},
keywords = {{polymer dissolution; mathematical model; controlled release; matrix; swelling}},
language = {{eng}},
number = {{3}},
pages = {{216--225}},
publisher = {{Elsevier}},
series = {{Journal of Controlled Release}},
title = {{A model for the drug release from a polymer matrix tablet - effects of swelling and dissolution}},
url = {{http://dx.doi.org/10.1016/j.jconrel.2006.05.004}},
doi = {{10.1016/j.jconrel.2006.05.004}},
volume = {{113}},
year = {{2006}},
}