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ARHGAP4 as a Prognostic Biomarker for Colon Liver Metastases After Surgical Resection

Torén, William LU ; Sasor, Agata LU ; Ansari, Daniel LU and Andersson, Roland LU (2024) In Anticancer research 44(6). p.2597-2604
Abstract

Background/Aim: To select and stratify patients for optimal treatment plans is challenging. Identification of cancer-related biomarkers that serve as predictors for prognosis and treatment response is essential to better predict treatment outcome and find future targets for therapy. Previous data has suggested ARHGAP4 as a relevant biomarker in colorectal cancer (CRC). The purpose of this study was to assess how ARHGAP4 expression affected patients undergoing surgery for colon liver metastasis (CLM) in terms of overall survival (OS). Patients and Methods: A total of 251 patients undergoing resection of CLM from 2006 to 2017 were included. Corresponding resected tumor specimens were examined for ARHGAP4 expression levels by... (More)

Background/Aim: To select and stratify patients for optimal treatment plans is challenging. Identification of cancer-related biomarkers that serve as predictors for prognosis and treatment response is essential to better predict treatment outcome and find future targets for therapy. Previous data has suggested ARHGAP4 as a relevant biomarker in colorectal cancer (CRC). The purpose of this study was to assess how ARHGAP4 expression affected patients undergoing surgery for colon liver metastasis (CLM) in terms of overall survival (OS). Patients and Methods: A total of 251 patients undergoing resection of CLM from 2006 to 2017 were included. Corresponding resected tumor specimens were examined for ARHGAP4 expression levels by immunohistochemistry (IHC). The correlation between ARHGAP4 expression and postoperative survival was analyzed. Results: High expression levels of ARHGAP4 were seen in 60% of patients. High expression levels of ARHGAP4 were correlated with adverse prognosis after hepatectomy due to CLM. Survival data generated using Cox proportional hazard model showed a statistically significant difference between high and low ARHGAP4 expression groups by univariate (HR=1.5, 95% CI=1.1-2.2) and multivariate (HR=1.5, 95% CI=1.0-2.1) analysis. In multivariate Cox regression, high ARHGAP4 expression, preoperative CEA levels and presence of vascular invasion by pathological examinations were independent predictive factors of overall survival. Conclusion: ARHGAP4 is a novel prognostic biomarker after resection of CLM.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ARHGAP4, Colonic liver metastases, prognostic biomarker, survival after surgery
in
Anticancer research
volume
44
issue
6
pages
8 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85195014649
  • pmid:38821620
ISSN
0250-7005
DOI
10.21873/anticanres.17065
language
English
LU publication?
yes
id
39b6d9d2-8e03-4877-bde4-88a52024e879
date added to LUP
2024-10-14 15:02:41
date last changed
2025-07-08 13:38:08
@article{39b6d9d2-8e03-4877-bde4-88a52024e879,
  abstract     = {{<p>Background/Aim: To select and stratify patients for optimal treatment plans is challenging. Identification of cancer-related biomarkers that serve as predictors for prognosis and treatment response is essential to better predict treatment outcome and find future targets for therapy. Previous data has suggested ARHGAP4 as a relevant biomarker in colorectal cancer (CRC). The purpose of this study was to assess how ARHGAP4 expression affected patients undergoing surgery for colon liver metastasis (CLM) in terms of overall survival (OS). Patients and Methods: A total of 251 patients undergoing resection of CLM from 2006 to 2017 were included. Corresponding resected tumor specimens were examined for ARHGAP4 expression levels by immunohistochemistry (IHC). The correlation between ARHGAP4 expression and postoperative survival was analyzed. Results: High expression levels of ARHGAP4 were seen in 60% of patients. High expression levels of ARHGAP4 were correlated with adverse prognosis after hepatectomy due to CLM. Survival data generated using Cox proportional hazard model showed a statistically significant difference between high and low ARHGAP4 expression groups by univariate (HR=1.5, 95% CI=1.1-2.2) and multivariate (HR=1.5, 95% CI=1.0-2.1) analysis. In multivariate Cox regression, high ARHGAP4 expression, preoperative CEA levels and presence of vascular invasion by pathological examinations were independent predictive factors of overall survival. Conclusion: ARHGAP4 is a novel prognostic biomarker after resection of CLM.</p>}},
  author       = {{Torén, William and Sasor, Agata and Ansari, Daniel and Andersson, Roland}},
  issn         = {{0250-7005}},
  keywords     = {{ARHGAP4; Colonic liver metastases; prognostic biomarker; survival after surgery}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2597--2604}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{ARHGAP4 as a Prognostic Biomarker for Colon Liver Metastases After Surgical Resection}},
  url          = {{http://dx.doi.org/10.21873/anticanres.17065}},
  doi          = {{10.21873/anticanres.17065}},
  volume       = {{44}},
  year         = {{2024}},
}