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Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.

Ejserholm, Fredrik LU ; Stegmayr, John LU ; Bauer, Patrik ; Johansson, Fredrik LU ; Wallman, Lars LU ; Bengtsson, Martin LU and Oredsson, Stina (2015) In Biomaterials research 19(19). p.1-10
Abstract
The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed... (More)
The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomaterials research
volume
19
issue
19
pages
1 - 10
publisher
BioMed Central (BMC)
external identifiers
  • pmid:26396744
  • pmid:26396744
  • scopus:85020427489
ISSN
2055-7124
DOI
10.1186/s40824-015-0041-3
language
English
LU publication?
yes
id
3a604b93-ac68-4dbe-999f-22fa6f75093d (old id 8035179)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26396744?dopt=Abstract
date added to LUP
2016-04-01 13:52:14
date last changed
2025-10-14 09:43:35
@article{3a604b93-ac68-4dbe-999f-22fa6f75093d,
  abstract     = {{The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals.}},
  author       = {{Ejserholm, Fredrik and Stegmayr, John and Bauer, Patrik and Johansson, Fredrik and Wallman, Lars and Bengtsson, Martin and Oredsson, Stina}},
  issn         = {{2055-7124}},
  language     = {{eng}},
  number       = {{19}},
  pages        = {{1--10}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Biomaterials research}},
  title        = {{Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.}},
  url          = {{https://lup.lub.lu.se/search/files/3637318/8852380.pdf}},
  doi          = {{10.1186/s40824-015-0041-3}},
  volume       = {{19}},
  year         = {{2015}},
}