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Required temporal resolution for accurate thoracic aortic pulse wave velocity measurements by phase-contrast magnetic resonance imaging and comparison with clinical standard applanation tonometry : Cardiovascular Spring Meeting

Dorniak, Karolina; Heiberg, Einar LU ; Hellmann, Marcin; Rawicz-Zegrzda, Dorota; Wesierska, Maria; Galaska, Rafal; Sabisz, Agnieszka; Szurowska, Edyta; Dudziak, Maria and Hedström, Erik LU (2016) In BMC Cardiovascular Disorders 16(1). p.1-9
Abstract
Background: Pulse wave velocity (PWV) is a biomarker for arterial stiffness, clinically assessed by applanation
tonometry (AT). Increased use of phase-contrast cardiac magnetic resonance (CMR) imaging allows for PWV
assessment with minor routine protocol additions. The aims were to investigate the acquired temporal resolution
needed for accurate and precise measurements of CMR-PWV, and develop a tool for CMR-PWV measurements.
Methods: Computer phantoms were generated for PWV = 2–20 m/s based on human CMR-PWV data. The PWV
measurements were performed in 13 healthy young subjects and 13 patients at risk for cardiovascular disease. The
CMR-PWV was measured by through-plane phase-contrast CMR in the ascending aorta and... (More)
Background: Pulse wave velocity (PWV) is a biomarker for arterial stiffness, clinically assessed by applanation
tonometry (AT). Increased use of phase-contrast cardiac magnetic resonance (CMR) imaging allows for PWV
assessment with minor routine protocol additions. The aims were to investigate the acquired temporal resolution
needed for accurate and precise measurements of CMR-PWV, and develop a tool for CMR-PWV measurements.
Methods: Computer phantoms were generated for PWV = 2–20 m/s based on human CMR-PWV data. The PWV
measurements were performed in 13 healthy young subjects and 13 patients at risk for cardiovascular disease. The
CMR-PWV was measured by through-plane phase-contrast CMR in the ascending aorta and at the diaphragm level.
Centre-line aortic distance was determined between flow planes. The AT-PWV was assessed within 2 h after CMR.
Three observers (CMR experience: 15, 4, and <1 year) determined CMR-PWV. The developed tool was based on the
flow-curve foot transit time for PWV quantification.
Results: Computer phantoms showed bias 0.27 ± 0.32 m/s for a temporal resolution of at least 30 ms. Intraobserver
variability for CMR-PWV were: 0 ± 0.03 m/s (15 years), -0.04 ± 0.33 m/s (4 years), and -0.02 ± 0.30 m/s (<1 year).
Interobserver variability for CMR-PWV was below 0.02 ± 0.38 m/s. The AT-PWV overestimated CMR-PWV by 1.1 ± 0.
7 m/s in healthy young subjects and 1.6 ± 2.7 m/s in patients.
Conclusions: An acquired temporal resolution of at least 30 ms should be used to obtain accurate and precise thoracic
aortic phase-contrast CMR-PWV. A new freely available research tool was used to measure PWV in healthy young
subjects and in patients, showing low intra- and interobserver variability also for less experienced CMR observers.
Keywords: Aorta, Pulse wave velocity, Temporal resolution, Magnetic resonance imaging, Phase contrast, Applanation
tonometry (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aorta, Applanation tonometry, Magnetic resonance imaging, Phase contrast, Pulse wave velocity, Temporal resolution
in
BMC Cardiovascular Disorders
volume
16
issue
1
pages
9 pages
publisher
BioMed Central
external identifiers
  • scopus:84991769687
  • wos:000380228500003
  • pmid:27387199
ISSN
1471-2261
DOI
10.1186/s12872-016-0292-5
language
English
LU publication?
yes
id
3ab6bf8a-9455-485d-8cf7-97354ba702a0
date added to LUP
2016-11-08 12:18:52
date last changed
2017-08-07 10:31:25
@article{3ab6bf8a-9455-485d-8cf7-97354ba702a0,
  abstract     = {Background: Pulse wave velocity (PWV) is a biomarker for arterial stiffness, clinically assessed by applanation<br>
tonometry (AT). Increased use of phase-contrast cardiac magnetic resonance (CMR) imaging allows for PWV<br>
assessment with minor routine protocol additions. The aims were to investigate the acquired temporal resolution<br>
needed for accurate and precise measurements of CMR-PWV, and develop a tool for CMR-PWV measurements.<br>
Methods: Computer phantoms were generated for PWV = 2–20 m/s based on human CMR-PWV data. The PWV<br>
measurements were performed in 13 healthy young subjects and 13 patients at risk for cardiovascular disease. The<br>
CMR-PWV was measured by through-plane phase-contrast CMR in the ascending aorta and at the diaphragm level.<br>
Centre-line aortic distance was determined between flow planes. The AT-PWV was assessed within 2 h after CMR.<br>
Three observers (CMR experience: 15, 4, and &lt;1 year) determined CMR-PWV. The developed tool was based on the<br>
flow-curve foot transit time for PWV quantification.<br>
Results: Computer phantoms showed bias 0.27 ± 0.32 m/s for a temporal resolution of at least 30 ms. Intraobserver<br>
variability for CMR-PWV were: 0 ± 0.03 m/s (15 years), -0.04 ± 0.33 m/s (4 years), and -0.02 ± 0.30 m/s (&lt;1 year).<br>
Interobserver variability for CMR-PWV was below 0.02 ± 0.38 m/s. The AT-PWV overestimated CMR-PWV by 1.1 ± 0.<br>
7 m/s in healthy young subjects and 1.6 ± 2.7 m/s in patients.<br>
Conclusions: An acquired temporal resolution of at least 30 ms should be used to obtain accurate and precise thoracic<br>
aortic phase-contrast CMR-PWV. A new freely available research tool was used to measure PWV in healthy young<br>
subjects and in patients, showing low intra- and interobserver variability also for less experienced CMR observers.<br>
Keywords: Aorta, Pulse wave velocity, Temporal resolution, Magnetic resonance imaging, Phase contrast, Applanation<br>
tonometry},
  articleno    = {110},
  author       = {Dorniak, Karolina and Heiberg, Einar and Hellmann, Marcin and Rawicz-Zegrzda, Dorota and Wesierska, Maria and Galaska, Rafal and Sabisz, Agnieszka and Szurowska, Edyta and Dudziak, Maria and Hedström, Erik},
  issn         = {1471-2261},
  keyword      = {Aorta,Applanation tonometry,Magnetic resonance imaging,Phase contrast,Pulse wave velocity,Temporal resolution},
  language     = {eng},
  month        = {03},
  number       = {1},
  pages        = {1--9},
  publisher    = {BioMed Central},
  series       = {BMC Cardiovascular Disorders},
  title        = {Required temporal resolution for accurate thoracic aortic pulse wave velocity measurements by phase-contrast magnetic resonance imaging and comparison with clinical standard applanation tonometry : Cardiovascular Spring Meeting},
  url          = {http://dx.doi.org/10.1186/s12872-016-0292-5},
  volume       = {16},
  year         = {2016},
}