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Tensor-valued diffusion MRI in under 3 minutes : an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors

Nilsson, Markus LU ; Szczepankiewicz, Filip LU ; Brabec, Jan LU ; Taylor, Marie ; Westin, Carl Fredrik ; Golby, Alexandra ; van Westen, Danielle LU and Sundgren, Pia C. LU (2020) In Magnetic Resonance in Medicine 83(2). p.608-620
Abstract

Purpose: To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods: B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluated by estimating the anisotropic kurtosis (MKA) and isotropic kurtosis (MKI), respectively. An extensive imaging protocol was compared with a 3-minutes protocol. Results: The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower... (More)

Purpose: To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods: B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluated by estimating the anisotropic kurtosis (MKA) and isotropic kurtosis (MKI), respectively. An extensive imaging protocol was compared with a 3-minutes protocol. Results: The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower microscopic anisotropy than meningiomas (MKA = 0.29 ± 0.06 vs. 0.45 ± 0.08, P = 0.003). Metastases had higher tissue heterogeneity (MKI = 0.57 ± 0.07) than both the glioblastomas (0.44 ± 0.06, P < 0.001) and meningiomas (0.46 ± 0.06, P = 0.03). Conclusion: Evaluation of the microscopic anisotropy and tissue heterogeneity in intracranial tumor patients is feasible in clinically relevant times frames.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diffusion MRI, microscopic anisotropy, tumor heterogeneity
in
Magnetic Resonance in Medicine
volume
83
issue
2
pages
608 - 620
publisher
Wiley Online Library
external identifiers
  • scopus:85073803598
  • pmid:31517401
ISSN
0740-3194
DOI
10.1002/mrm.27959
language
English
LU publication?
yes
id
3b286509-67dd-42c1-a4a6-98514a5d2269
date added to LUP
2019-11-01 09:23:52
date last changed
2020-02-19 05:41:17
@article{3b286509-67dd-42c1-a4a6-98514a5d2269,
  abstract     = {<p>Purpose: To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods: B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluated by estimating the anisotropic kurtosis (MK<sub>A</sub>) and isotropic kurtosis (MK<sub>I</sub>), respectively. An extensive imaging protocol was compared with a 3-minutes protocol. Results: The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower microscopic anisotropy than meningiomas (MK<sub>A</sub> = 0.29 ± 0.06 vs. 0.45 ± 0.08, P = 0.003). Metastases had higher tissue heterogeneity (MK<sub>I</sub> = 0.57 ± 0.07) than both the glioblastomas (0.44 ± 0.06, P &lt; 0.001) and meningiomas (0.46 ± 0.06, P = 0.03). Conclusion: Evaluation of the microscopic anisotropy and tissue heterogeneity in intracranial tumor patients is feasible in clinically relevant times frames.</p>},
  author       = {Nilsson, Markus and Szczepankiewicz, Filip and Brabec, Jan and Taylor, Marie and Westin, Carl Fredrik and Golby, Alexandra and van Westen, Danielle and Sundgren, Pia C.},
  issn         = {0740-3194},
  language     = {eng},
  number       = {2},
  pages        = {608--620},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Tensor-valued diffusion MRI in under 3 minutes : an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors},
  url          = {http://dx.doi.org/10.1002/mrm.27959},
  doi          = {10.1002/mrm.27959},
  volume       = {83},
  year         = {2020},
}