Dopamine agonist serum concentrations and impulse control disorders in Parkinson's disease
(2023) In European Journal of Neurology- Abstract
Background and purpose: Impulse control disorders (ICDs) are common among Parkinson's disease patients using dopamine agonists. We wanted to determine whether ICD patients have higher dopamine agonist serum concentrations than those without any sign of ICD. Methods: Patients who used either pramipexole or ropinirole depot once daily were screened for ICDs using the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease–Rating Scale. Those who scored above the cut-off for one or more of the four defined ICDs (gambling, compulsive sexual behavior, compulsive shopping, and binge-eating) were compared in a case–control study to patients who scored zero points (no evidence of ICD) on the same items. They were... (More)
Background and purpose: Impulse control disorders (ICDs) are common among Parkinson's disease patients using dopamine agonists. We wanted to determine whether ICD patients have higher dopamine agonist serum concentrations than those without any sign of ICD. Methods: Patients who used either pramipexole or ropinirole depot once daily were screened for ICDs using the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease–Rating Scale. Those who scored above the cut-off for one or more of the four defined ICDs (gambling, compulsive sexual behavior, compulsive shopping, and binge-eating) were compared in a case–control study to patients who scored zero points (no evidence of ICD) on the same items. They were examined clinically and evaluated using relevant scales. Three blood samples were taken on the same day: before daily dose, and then 6 and 12 h later. Results: Forty-six patients were included: 19 ICD-positive and 27 controls. Ropinirole serum concentrations 6 h after daily intake (Cmax) were higher in the case group compared to the control group, as was the daily ropinirole dosage. No differences were observed in serum concentrations, dosage or total drug exposure for pramipexole. Disease duration and length of dopamine agonist treatment was significantly longer among ICD patients for ropinirole, but not for pramipexole. Conclusions: The use of pramipexole may in itself confer high ICD risk, whereas ICDs among ropinirole users depend more on serum concentration and drug exposure. The pharmacokinetic properties of ropinirole make it challenging to predict its effects on patients, which supports the need for therapeutic drug monitoring to reduce risk of ICD.
(Less)
- author
- Staubo, Sara C.
; Fuskevåg, Ole Martin
; Toft, Mathias
; Lie, Ingeborg H.
; Alvik, Kirsti M.J.
; Jostad, Pål
; Tingvoll, Stein H.
; Lilleng, Hallvard
; Rosqvist, Kristina
LU
; Størset, Elisabet
; Odin, Per
LU
; Dietrichs, Espen
and Dietrichs, Erik Sveberg
(Less) - organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- in press
- subject
- keywords
- dopamine agonist, impulse control disorders – pharmacology, Parkinson's disease
- in
- European Journal of Neurology
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:37955562
- scopus:85176747298
- ISSN
- 1351-5101
- DOI
- 10.1111/ene.16144
- language
- English
- LU publication?
- yes
- id
- 3b61d2b2-43fc-490c-9f15-40d563a810da
- date added to LUP
- 2024-01-11 11:10:20
- date last changed
- 2024-04-12 04:02:38
@article{3b61d2b2-43fc-490c-9f15-40d563a810da,
abstract = {{<p>Background and purpose: Impulse control disorders (ICDs) are common among Parkinson's disease patients using dopamine agonists. We wanted to determine whether ICD patients have higher dopamine agonist serum concentrations than those without any sign of ICD. Methods: Patients who used either pramipexole or ropinirole depot once daily were screened for ICDs using the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease–Rating Scale. Those who scored above the cut-off for one or more of the four defined ICDs (gambling, compulsive sexual behavior, compulsive shopping, and binge-eating) were compared in a case–control study to patients who scored zero points (no evidence of ICD) on the same items. They were examined clinically and evaluated using relevant scales. Three blood samples were taken on the same day: before daily dose, and then 6 and 12 h later. Results: Forty-six patients were included: 19 ICD-positive and 27 controls. Ropinirole serum concentrations 6 h after daily intake (C<sub>max</sub>) were higher in the case group compared to the control group, as was the daily ropinirole dosage. No differences were observed in serum concentrations, dosage or total drug exposure for pramipexole. Disease duration and length of dopamine agonist treatment was significantly longer among ICD patients for ropinirole, but not for pramipexole. Conclusions: The use of pramipexole may in itself confer high ICD risk, whereas ICDs among ropinirole users depend more on serum concentration and drug exposure. The pharmacokinetic properties of ropinirole make it challenging to predict its effects on patients, which supports the need for therapeutic drug monitoring to reduce risk of ICD.</p>}},
author = {{Staubo, Sara C. and Fuskevåg, Ole Martin and Toft, Mathias and Lie, Ingeborg H. and Alvik, Kirsti M.J. and Jostad, Pål and Tingvoll, Stein H. and Lilleng, Hallvard and Rosqvist, Kristina and Størset, Elisabet and Odin, Per and Dietrichs, Espen and Dietrichs, Erik Sveberg}},
issn = {{1351-5101}},
keywords = {{dopamine agonist; impulse control disorders – pharmacology; Parkinson's disease}},
language = {{eng}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neurology}},
title = {{Dopamine agonist serum concentrations and impulse control disorders in Parkinson's disease}},
url = {{http://dx.doi.org/10.1111/ene.16144}},
doi = {{10.1111/ene.16144}},
year = {{2023}},
}