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Self-assembly and surface behaviour of pure and mixed zwitterionic amphiphiles in a deep eutectic solvent

Sanchez-Fernandez, A. LU ; Moody, G. L.; Murfin, L. C.; Arnold, T.; Jackson, A. J. LU ; King, S. M.; Lewis, S. E. and Edler, K. J. LU (2018) In Soft Matter 14(26). p.5525-5536
Abstract

Recent investigations have shown that deep eutectic solvents provide a suitable environment for self-organisation of biomolecules, in particular phospholipids and proteins. However, the solvation of complex lyophilic moieties by deep eutectic solvents still remains unclear. Here we explore the behaviour of zwitterionic surfactants in choline chloride:glycerol eutectic mixture. Dodecyl-2-(trimethylammonio)ethylphosphate and N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (alkyl = dodecyl, tetradecyl) surfactants were investigated by means of surface tension, X-ray reflectivity and small-angle neutron scattering. These surfactants were found to remain surface active and form globular micelles in deep eutectic solvents. Still, the... (More)

Recent investigations have shown that deep eutectic solvents provide a suitable environment for self-organisation of biomolecules, in particular phospholipids and proteins. However, the solvation of complex lyophilic moieties by deep eutectic solvents still remains unclear. Here we explore the behaviour of zwitterionic surfactants in choline chloride:glycerol eutectic mixture. Dodecyl-2-(trimethylammonio)ethylphosphate and N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (alkyl = dodecyl, tetradecyl) surfactants were investigated by means of surface tension, X-ray reflectivity and small-angle neutron scattering. These surfactants were found to remain surface active and form globular micelles in deep eutectic solvents. Still, the surface behaviour of these species was found to differ depending on the headgroup and tail structure. The morphology of the micelles also slightly varies between surfactants, demonstrating differences in the packing of individual monomers. The characteristics of mixtures of the dodecyl surfactants is also reported, showing a deviation from ideal mixing associated with attractive interactions between sulfobetaine and phosphocholine headgroups. Such non-ideality results in variation of the surface behaviour and self-assembly of these surfactant mixtures. The results presented here will potentially lead to the development of new alternatives for drug-delivery, protein solubilisation and biosensing through a better fundamental understanding of the behaviour of zwitterionic surfactants in deep eutectic solvents.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
14
issue
26
pages
12 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85049501892
ISSN
1744-683X
DOI
10.1039/c8sm00755a
language
English
LU publication?
yes
id
3b75374a-d73b-4b33-b9f6-043c36960d47
date added to LUP
2018-07-26 10:29:47
date last changed
2019-07-16 03:53:37
@article{3b75374a-d73b-4b33-b9f6-043c36960d47,
  abstract     = {<p>Recent investigations have shown that deep eutectic solvents provide a suitable environment for self-organisation of biomolecules, in particular phospholipids and proteins. However, the solvation of complex lyophilic moieties by deep eutectic solvents still remains unclear. Here we explore the behaviour of zwitterionic surfactants in choline chloride:glycerol eutectic mixture. Dodecyl-2-(trimethylammonio)ethylphosphate and N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (alkyl = dodecyl, tetradecyl) surfactants were investigated by means of surface tension, X-ray reflectivity and small-angle neutron scattering. These surfactants were found to remain surface active and form globular micelles in deep eutectic solvents. Still, the surface behaviour of these species was found to differ depending on the headgroup and tail structure. The morphology of the micelles also slightly varies between surfactants, demonstrating differences in the packing of individual monomers. The characteristics of mixtures of the dodecyl surfactants is also reported, showing a deviation from ideal mixing associated with attractive interactions between sulfobetaine and phosphocholine headgroups. Such non-ideality results in variation of the surface behaviour and self-assembly of these surfactant mixtures. The results presented here will potentially lead to the development of new alternatives for drug-delivery, protein solubilisation and biosensing through a better fundamental understanding of the behaviour of zwitterionic surfactants in deep eutectic solvents.</p>},
  author       = {Sanchez-Fernandez, A. and Moody, G. L. and Murfin, L. C. and Arnold, T. and Jackson, A. J. and King, S. M. and Lewis, S. E. and Edler, K. J.},
  issn         = {1744-683X},
  language     = {eng},
  month        = {01},
  number       = {26},
  pages        = {5525--5536},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Self-assembly and surface behaviour of pure and mixed zwitterionic amphiphiles in a deep eutectic solvent},
  url          = {http://dx.doi.org/10.1039/c8sm00755a},
  volume       = {14},
  year         = {2018},
}