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Centrosomal Abnormalities in Pancreatic Cancer : Molecular Mechanisms and Clinical Implications

Ansari, Daniel LU ; Del Pino Bellido, Carolina; Bauden, Monika LU and Andersson, Roland LU (2018) In Anticancer research 38(3). p.1241-1245
Abstract

The centrosome is the main microtubule-organizing center in human cells. It regulates normal cell-cycle progression and cell division. Aberrations in the number, structure and function of centrosomes have been found to drive genomic instability and tumorigenesis. Pancreatic cancer frequently displays centrosomal aberrations. Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. In this review, we summarize recent advances in the understanding of centrosomal aberrations in pancreatic cancer, focusing on regulatory mechanisms and prospects for future anticancer treatment.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Centrosomal abnormalities, Molecular mechanisms, Pancreatic cancer, Review, Treatment
in
Anticancer research
volume
38
issue
3
pages
1241 - 1245
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85043444985
ISSN
0250-7005
DOI
10.21873/anticanres.12345
language
English
LU publication?
yes
id
3bc8ca4a-abf3-4b31-9936-777d92dda9fc
date added to LUP
2018-04-09 13:50:06
date last changed
2019-01-06 13:50:15
@article{3bc8ca4a-abf3-4b31-9936-777d92dda9fc,
  abstract     = {<p>The centrosome is the main microtubule-organizing center in human cells. It regulates normal cell-cycle progression and cell division. Aberrations in the number, structure and function of centrosomes have been found to drive genomic instability and tumorigenesis. Pancreatic cancer frequently displays centrosomal aberrations. Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. In this review, we summarize recent advances in the understanding of centrosomal aberrations in pancreatic cancer, focusing on regulatory mechanisms and prospects for future anticancer treatment.</p>},
  author       = {Ansari, Daniel and Del Pino Bellido, Carolina and Bauden, Monika and Andersson, Roland},
  issn         = {0250-7005},
  keyword      = {Centrosomal abnormalities,Molecular mechanisms,Pancreatic cancer,Review,Treatment},
  language     = {eng},
  month        = {03},
  number       = {3},
  pages        = {1241--1245},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer research},
  title        = {Centrosomal Abnormalities in Pancreatic Cancer : Molecular Mechanisms and Clinical Implications},
  url          = {http://dx.doi.org/10.21873/anticanres.12345},
  volume       = {38},
  year         = {2018},
}