Centrosomal Abnormalities in Pancreatic Cancer : Molecular Mechanisms and Clinical Implications
Ansari, Daniel LU ; Del Pino Bellido, Carolina ; Bauden, Monika LU
and Andersson, Roland
LU
(2018)
In Anticancer research
38(3).
p.1241-1245
- Abstract
The centrosome is the main microtubule-organizing center in human cells. It regulates normal cell-cycle progression and cell division. Aberrations in the number, structure and function of centrosomes have been found to drive genomic instability and tumorigenesis. Pancreatic cancer frequently displays centrosomal aberrations. Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. In this review, we summarize recent advances in the understanding of centrosomal aberrations in pancreatic cancer, focusing on regulatory mechanisms and prospects for future anticancer treatment.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3bc8ca4a-abf3-4b31-9936-777d92dda9fc
- author
- Ansari, Daniel
LU
; Del Pino Bellido, Carolina
; Bauden, Monika
LU
and Andersson, Roland
LU
- organization
- publishing date
- 2018-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Centrosomal abnormalities, Molecular mechanisms, Pancreatic cancer, Review, Treatment
- in
- Anticancer research
- volume
- 38
- issue
- 3
- pages
- 1241 - 1245
- publisher
- International Institute of Cancer Research
- external identifiers
-
- scopus:85043444985
- pmid:29491046
- ISSN
- 0250-7005
- DOI
- 10.21873/anticanres.12345
- language
- English
- LU publication?
- yes
- id
- 3bc8ca4a-abf3-4b31-9936-777d92dda9fc
- date added to LUP
- 2018-04-09 13:50:06
- date last changed
- 2024-06-10 10:42:41
@article{3bc8ca4a-abf3-4b31-9936-777d92dda9fc,
abstract = {{<p>The centrosome is the main microtubule-organizing center in human cells. It regulates normal cell-cycle progression and cell division. Aberrations in the number, structure and function of centrosomes have been found to drive genomic instability and tumorigenesis. Pancreatic cancer frequently displays centrosomal aberrations. Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. In this review, we summarize recent advances in the understanding of centrosomal aberrations in pancreatic cancer, focusing on regulatory mechanisms and prospects for future anticancer treatment.</p>}},
author = {{Ansari, Daniel and Del Pino Bellido, Carolina and Bauden, Monika and Andersson, Roland}},
issn = {{0250-7005}},
keywords = {{Centrosomal abnormalities; Molecular mechanisms; Pancreatic cancer; Review; Treatment}},
language = {{eng}},
month = {{03}},
number = {{3}},
pages = {{1241--1245}},
publisher = {{International Institute of Cancer Research}},
series = {{Anticancer research}},
title = {{Centrosomal Abnormalities in Pancreatic Cancer : Molecular Mechanisms and Clinical Implications}},
url = {{http://dx.doi.org/10.21873/anticanres.12345}},
doi = {{10.21873/anticanres.12345}},
volume = {{38}},
year = {{2018}},
}