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Intraplatelet cyclic 3'-5' guanosine monophosphate is related to serum cholesterol

Anwaar, I. ; Gottsäter, A. LU ; Wallmark, A. LU ; Hedblad, B. LU ; Lindgärde, F. LU and Mattiasson, I. LU (1996) In International Angiology 15(3). p.201-206
Abstract

Nitric oxide (NO) exerts its vasodilator and antiaggregatory effects through activation of soluble guanylate cyclase and the consequent increase in the concentration of cGMP in target cells. We conducted this study in order to evaluate relationships between intraplatelet cGMP levels and risk factors for atherosclerosis in middle aged subjects. Intraplatelet cGMP was determined by radioimmunoassay and related to age, BMI, blood pressure, antihypertensive treatment, total, LDL and HDL cholesterol, triglycerides, blood glucose, HbA1c, smoking habit and intimal thickness of the common carotid artery in 265 subjects participating in a health survey (age 59 ± 6 years, range 48-68 years, 121 females, 144 males). Intraplatelet cGMP... (More)

Nitric oxide (NO) exerts its vasodilator and antiaggregatory effects through activation of soluble guanylate cyclase and the consequent increase in the concentration of cGMP in target cells. We conducted this study in order to evaluate relationships between intraplatelet cGMP levels and risk factors for atherosclerosis in middle aged subjects. Intraplatelet cGMP was determined by radioimmunoassay and related to age, BMI, blood pressure, antihypertensive treatment, total, LDL and HDL cholesterol, triglycerides, blood glucose, HbA1c, smoking habit and intimal thickness of the common carotid artery in 265 subjects participating in a health survey (age 59 ± 6 years, range 48-68 years, 121 females, 144 males). Intraplatelet cGMP concentration was inversely correlated with total serum cholesterol (r = -0.18; p < 0.01) and HDL cholesterol (r = -0.14, p < 0.05) as well as with platelet count (r = -0.29; p < 0.001). When platelet count was adjusted for, only the correlation between total serum cholesterol and cGMP remained significant. No significant correlations could be demonstrated between intraplatelet cGMP levels and measurable parameters of atherosclerosis. Lower levels of the vasodilating and antiaggregating mediator cGMP in platelets are related to higher levels of serum total cholesterol. These results favour the hypothesis of a relationship between lipid levels and NO associated vasodilator and antiaggregating fuction in atherosclerosis.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, Endothelium, Platelets
in
International Angiology
volume
15
issue
3
pages
6 pages
publisher
Minerva Medica
external identifiers
  • scopus:0029844754
  • pmid:8971576
ISSN
0392-9590
language
English
LU publication?
yes
id
3bea4f38-0683-4371-9ce7-9ca05871fa61
date added to LUP
2020-12-11 14:32:52
date last changed
2024-01-03 00:53:40
@article{3bea4f38-0683-4371-9ce7-9ca05871fa61,
  abstract     = {{<p>Nitric oxide (NO) exerts its vasodilator and antiaggregatory effects through activation of soluble guanylate cyclase and the consequent increase in the concentration of cGMP in target cells. We conducted this study in order to evaluate relationships between intraplatelet cGMP levels and risk factors for atherosclerosis in middle aged subjects. Intraplatelet cGMP was determined by radioimmunoassay and related to age, BMI, blood pressure, antihypertensive treatment, total, LDL and HDL cholesterol, triglycerides, blood glucose, HbA1c, smoking habit and intimal thickness of the common carotid artery in 265 subjects participating in a health survey (age 59 ± 6 years, range 48-68 years, 121 females, 144 males). Intraplatelet cGMP concentration was inversely correlated with total serum cholesterol (r = -0.18; p &lt; 0.01) and HDL cholesterol (r = -0.14, p &lt; 0.05) as well as with platelet count (r = -0.29; p &lt; 0.001). When platelet count was adjusted for, only the correlation between total serum cholesterol and cGMP remained significant. No significant correlations could be demonstrated between intraplatelet cGMP levels and measurable parameters of atherosclerosis. Lower levels of the vasodilating and antiaggregating mediator cGMP in platelets are related to higher levels of serum total cholesterol. These results favour the hypothesis of a relationship between lipid levels and NO associated vasodilator and antiaggregating fuction in atherosclerosis.</p>}},
  author       = {{Anwaar, I. and Gottsäter, A. and Wallmark, A. and Hedblad, B. and Lindgärde, F. and Mattiasson, I.}},
  issn         = {{0392-9590}},
  keywords     = {{Atherosclerosis; Endothelium; Platelets}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{201--206}},
  publisher    = {{Minerva Medica}},
  series       = {{International Angiology}},
  title        = {{Intraplatelet cyclic 3'-5' guanosine monophosphate is related to serum cholesterol}},
  volume       = {{15}},
  year         = {{1996}},
}