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Removal of pharmaceutical metabolites in wastewater ozonation including their fate in different post-treatments

Kharel, Suman ; Stapf, Michael ; Miehe, Ulf ; Ekblad, Maja LU ; Cimbritz, Michael LU ; Falås, Per LU ; Nilsson, Josefine ; Sehlén, Robert ; Bregendahl, Jeppe and Bester, Kai (2021) In Science of the Total Environment 759.
Abstract

Advanced treatment technologies for the removal of pharmaceuticals and other organic micropollutants in WWTPs primarily target the removal of parent compounds. Nevertheless, the removal of metabolites originating from human- or microbial metabolism during biological treatment needs comparable consideration, as some of them might be present in high concentrations and contribute to toxicity. This study was conducted to elucidate the removal of human and microbial metabolites of pharmaceuticals as a function of the specific ozone dose. Ozonation was performed on four sites with two pilot- and two full-scale plants operated downstream of conventional activated sludge plants. The ozone reactivity of all metabolites (expressed as the ozone... (More)

Advanced treatment technologies for the removal of pharmaceuticals and other organic micropollutants in WWTPs primarily target the removal of parent compounds. Nevertheless, the removal of metabolites originating from human- or microbial metabolism during biological treatment needs comparable consideration, as some of them might be present in high concentrations and contribute to toxicity. This study was conducted to elucidate the removal of human and microbial metabolites of pharmaceuticals as a function of the specific ozone dose. Ozonation was performed on four sites with two pilot- and two full-scale plants operated downstream of conventional activated sludge plants. The ozone reactivity of all metabolites (expressed as the ozone dose to remove 90% of the compound/decadic ozone dose) was lower than those of their parent compounds. The decadic ozone dose was 1.0, 1.3 and 1.1 mg O3/mg DOC for Epoxy-carbamazepine, Di-OH-carbamazepine and N-Desmethyl tramadol, respectively. 20–40% of the remaining metabolites were removed in a polishing sand/BAC-filter (biological activated carbon). Similar removal was observed for Epoxy-carbamazepine, Di-OH-carbamazepine and Hydroxy-diclofenac in a constructed wetland. However, the sand/anthracite filter had no effect. All four metabolites were removed in a GAC (granulated activated carbon) filter.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ozonation, Pharmaceutical metabolites, Post-treatment, Removal, Wastewater
in
Science of the Total Environment
volume
759
article number
143989
publisher
Elsevier
external identifiers
  • pmid:33321442
  • scopus:85097710932
ISSN
0048-9697
DOI
10.1016/j.scitotenv.2020.143989
language
English
LU publication?
yes
id
3bf97150-5fd1-4bb1-993d-8646a1077030
date added to LUP
2021-01-04 10:52:55
date last changed
2021-03-24 05:18:59
@article{3bf97150-5fd1-4bb1-993d-8646a1077030,
  abstract     = {<p>Advanced treatment technologies for the removal of pharmaceuticals and other organic micropollutants in WWTPs primarily target the removal of parent compounds. Nevertheless, the removal of metabolites originating from human- or microbial metabolism during biological treatment needs comparable consideration, as some of them might be present in high concentrations and contribute to toxicity. This study was conducted to elucidate the removal of human and microbial metabolites of pharmaceuticals as a function of the specific ozone dose. Ozonation was performed on four sites with two pilot- and two full-scale plants operated downstream of conventional activated sludge plants. The ozone reactivity of all metabolites (expressed as the ozone dose to remove 90% of the compound/decadic ozone dose) was lower than those of their parent compounds. The decadic ozone dose was 1.0, 1.3 and 1.1 mg O<sub>3</sub>/mg DOC for Epoxy-carbamazepine, Di-OH-carbamazepine and N-Desmethyl tramadol, respectively. 20–40% of the remaining metabolites were removed in a polishing sand/BAC-filter (biological activated carbon). Similar removal was observed for Epoxy-carbamazepine, Di-OH-carbamazepine and Hydroxy-diclofenac in a constructed wetland. However, the sand/anthracite filter had no effect. All four metabolites were removed in a GAC (granulated activated carbon) filter.</p>},
  author       = {Kharel, Suman and Stapf, Michael and Miehe, Ulf and Ekblad, Maja and Cimbritz, Michael and Falås, Per and Nilsson, Josefine and Sehlén, Robert and Bregendahl, Jeppe and Bester, Kai},
  issn         = {0048-9697},
  language     = {eng},
  publisher    = {Elsevier},
  series       = {Science of the Total Environment},
  title        = {Removal of pharmaceutical metabolites in wastewater ozonation including their fate in different post-treatments},
  url          = {http://dx.doi.org/10.1016/j.scitotenv.2020.143989},
  doi          = {10.1016/j.scitotenv.2020.143989},
  volume       = {759},
  year         = {2021},
}