Removal of pharmaceutical metabolites in wastewater ozonation including their fate in different post-treatments
(2021) In Science of the Total Environment 759.- Abstract
Advanced treatment technologies for the removal of pharmaceuticals and other organic micropollutants in WWTPs primarily target the removal of parent compounds. Nevertheless, the removal of metabolites originating from human- or microbial metabolism during biological treatment needs comparable consideration, as some of them might be present in high concentrations and contribute to toxicity. This study was conducted to elucidate the removal of human and microbial metabolites of pharmaceuticals as a function of the specific ozone dose. Ozonation was performed on four sites with two pilot- and two full-scale plants operated downstream of conventional activated sludge plants. The ozone reactivity of all metabolites (expressed as the ozone... (More)
Advanced treatment technologies for the removal of pharmaceuticals and other organic micropollutants in WWTPs primarily target the removal of parent compounds. Nevertheless, the removal of metabolites originating from human- or microbial metabolism during biological treatment needs comparable consideration, as some of them might be present in high concentrations and contribute to toxicity. This study was conducted to elucidate the removal of human and microbial metabolites of pharmaceuticals as a function of the specific ozone dose. Ozonation was performed on four sites with two pilot- and two full-scale plants operated downstream of conventional activated sludge plants. The ozone reactivity of all metabolites (expressed as the ozone dose to remove 90% of the compound/decadic ozone dose) was lower than those of their parent compounds. The decadic ozone dose was 1.0, 1.3 and 1.1 mg O3/mg DOC for Epoxy-carbamazepine, Di-OH-carbamazepine and N-Desmethyl tramadol, respectively. 20–40% of the remaining metabolites were removed in a polishing sand/BAC-filter (biological activated carbon). Similar removal was observed for Epoxy-carbamazepine, Di-OH-carbamazepine and Hydroxy-diclofenac in a constructed wetland. However, the sand/anthracite filter had no effect. All four metabolites were removed in a GAC (granulated activated carbon) filter.
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- author
- Kharel, Suman ; Stapf, Michael ; Miehe, Ulf ; Ekblad, Maja LU ; Cimbritz, Michael LU ; Falås, Per LU ; Nilsson, Josefine ; Sehlén, Robert ; Bregendahl, Jeppe and Bester, Kai
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Ozonation, Pharmaceutical metabolites, Post-treatment, Removal, Wastewater
- in
- Science of the Total Environment
- volume
- 759
- article number
- 143989
- publisher
- Elsevier
- external identifiers
-
- pmid:33321442
- scopus:85097710932
- ISSN
- 0048-9697
- DOI
- 10.1016/j.scitotenv.2020.143989
- language
- English
- LU publication?
- yes
- id
- 3bf97150-5fd1-4bb1-993d-8646a1077030
- date added to LUP
- 2021-01-04 10:52:55
- date last changed
- 2024-04-17 22:07:24
@article{3bf97150-5fd1-4bb1-993d-8646a1077030,
abstract = {{<p>Advanced treatment technologies for the removal of pharmaceuticals and other organic micropollutants in WWTPs primarily target the removal of parent compounds. Nevertheless, the removal of metabolites originating from human- or microbial metabolism during biological treatment needs comparable consideration, as some of them might be present in high concentrations and contribute to toxicity. This study was conducted to elucidate the removal of human and microbial metabolites of pharmaceuticals as a function of the specific ozone dose. Ozonation was performed on four sites with two pilot- and two full-scale plants operated downstream of conventional activated sludge plants. The ozone reactivity of all metabolites (expressed as the ozone dose to remove 90% of the compound/decadic ozone dose) was lower than those of their parent compounds. The decadic ozone dose was 1.0, 1.3 and 1.1 mg O<sub>3</sub>/mg DOC for Epoxy-carbamazepine, Di-OH-carbamazepine and N-Desmethyl tramadol, respectively. 20–40% of the remaining metabolites were removed in a polishing sand/BAC-filter (biological activated carbon). Similar removal was observed for Epoxy-carbamazepine, Di-OH-carbamazepine and Hydroxy-diclofenac in a constructed wetland. However, the sand/anthracite filter had no effect. All four metabolites were removed in a GAC (granulated activated carbon) filter.</p>}},
author = {{Kharel, Suman and Stapf, Michael and Miehe, Ulf and Ekblad, Maja and Cimbritz, Michael and Falås, Per and Nilsson, Josefine and Sehlén, Robert and Bregendahl, Jeppe and Bester, Kai}},
issn = {{0048-9697}},
keywords = {{Ozonation; Pharmaceutical metabolites; Post-treatment; Removal; Wastewater}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Science of the Total Environment}},
title = {{Removal of pharmaceutical metabolites in wastewater ozonation including their fate in different post-treatments}},
url = {{http://dx.doi.org/10.1016/j.scitotenv.2020.143989}},
doi = {{10.1016/j.scitotenv.2020.143989}},
volume = {{759}},
year = {{2021}},
}